TY - JOUR
T1 - Hyaluronic acid coated nano-particles for H2O2-elevation augmented photo-/chemodynamic therapy
AU - Bai, Yang
AU - Wang, Ruiqi
AU - Wang, Xiaoning
AU - Duan, Xiao
AU - Yan, Xiaochen
AU - Liu, Chengfei
AU - Tian, Wei
N1 - Publisher Copyright:
© 2023
PY - 2023/8/1
Y1 - 2023/8/1
N2 - In recent years, the association of chemodynamic therapy (CDT) with photodynamic therapy (PDT) has attracted much attention due to their mutually reinforced property. Nevertheless, how to further strengthen their performance is still a big challenge. Given the PDT/CDT therapeutic mechanism, the H2O2 amount might affect their final performance. Thus, in this paper, our synthesized pH-responsive Fenton agents (ferrocene-cinnamaldehyde conjugates, Fc-CA) were encapsulated in hyaluronic acid (HA) coated porphyrin-based MOF to obtain supramolecular nano-particles (Fc-CA-PCN-HA). After the CD44-receptor mediated internalization, the released Fc-CA could further dissociate in the acidic pH micro-environment. The released CA can activate the NADPH oxidase to elevate the H2O2 amount which could be preferable to produce more ·OH through Fenton reaction for cancer cells apoptosis. Additionally, O2 was also generated in the CDT which could alleviate tumor hypoxia condition and be provided as the reactant for PDT to produce more 1O2. Thus, given the excellent cascade reactions induced therapeutic performance of Fc-CA-PCN-HA in vitro and in vivo, the H2O2-elevation strategy might further enhance the PDT/CDT outcomes.
AB - In recent years, the association of chemodynamic therapy (CDT) with photodynamic therapy (PDT) has attracted much attention due to their mutually reinforced property. Nevertheless, how to further strengthen their performance is still a big challenge. Given the PDT/CDT therapeutic mechanism, the H2O2 amount might affect their final performance. Thus, in this paper, our synthesized pH-responsive Fenton agents (ferrocene-cinnamaldehyde conjugates, Fc-CA) were encapsulated in hyaluronic acid (HA) coated porphyrin-based MOF to obtain supramolecular nano-particles (Fc-CA-PCN-HA). After the CD44-receptor mediated internalization, the released Fc-CA could further dissociate in the acidic pH micro-environment. The released CA can activate the NADPH oxidase to elevate the H2O2 amount which could be preferable to produce more ·OH through Fenton reaction for cancer cells apoptosis. Additionally, O2 was also generated in the CDT which could alleviate tumor hypoxia condition and be provided as the reactant for PDT to produce more 1O2. Thus, given the excellent cascade reactions induced therapeutic performance of Fc-CA-PCN-HA in vitro and in vivo, the H2O2-elevation strategy might further enhance the PDT/CDT outcomes.
KW - Chemodynamic therapy
KW - Combined therapy
KW - Photodynamic therapy
KW - Stimuli-responsive property
UR - http://www.scopus.com/inward/record.url?scp=85163187640&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2023.125523
DO - 10.1016/j.ijbiomac.2023.125523
M3 - 文章
C2 - 37356681
AN - SCOPUS:85163187640
SN - 0141-8130
VL - 245
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
M1 - 125523
ER -
