High-Quality Genome Assembly of Eriocheir japonica sinensis Reveals Its Unique Genome Evolution

Boping Tang, Zhongkai Wang, Qiuning Liu, Huabin Zhang, Senhao Jiang, Xinzheng Li, Zhengfei Wang, Yue Sun, Zhongli Sha, Hui Jiang, Xugan Wu, Yandong Ren, Haorong Li, Fujun Xuan, Baoming Ge, Wei Jiang, Shusheng She, Hongying Sun, Qiang Qiu, Wen WangQun Wang, Gaofeng Qiu, Daizhen Zhang, Yongxin Li

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

As an important freshwater aquaculture species in China, the Chinese mitten crab (Eriocheir japonica sinensis) has high economic and nutritional value. However, limited genomic information is currently available for studying its basic development and genetic diversity. Here, we performed whole-genome sequencing on Oxford Nanopore Technologies Limited's platform using promethION. The assembled size of E. j.sinensis genome was approximately 1.27 Gb, which is close to the estimated size (1.19 Gb). Furthermore, based on assessment using Benchmarking Universal Single-Copy Orthologs (BUSCO) (Simao et al., 2015), 94.00% of the expected eukaryotic genes were completely present in the genome assembly. In addition, repetitive sequences accounted for ~61.42% of the assembled genome, and 22,619 protein-coding genes were annotated. Comparative genomics analysis demonstrated that the Chinese mitten crab diverged from Penaeus vannamei ~373.6 million years ago, with a faster evolution rate than shrimp. We anticipate that the annotated high-quality genome of E. j. sinensis will promote research on its basic development and evolution and make substantial contributions to comparative genomic analyses of crustaceans.

Original languageEnglish
Article number1340
JournalFrontiers in Genetics
Volume10
DOIs
StatePublished - 17 Jan 2020

Keywords

  • crab
  • Eriocheir japonica sinensis
  • evolution
  • genome assembly and annotation
  • nanopore

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