General synthesis of (1-substituted-1H-1,2,3-triazol-4-ylmethyl)- dialkylamines via a copper(I)-catalyzed three-component reaction in water

Ze Yi Yan; Ya Bin Zhao; Ming Jin Fan; Wei Min Liu; Yong Min Liang

doi:10.1016/j.tet.2005.07.060

General synthesis of (1-substituted-1H-1,2,3-triazol-4-ylmethyl)- dialkylamines via a copper(I)-catalyzed three-component reaction in water

Ze Yi Yan, Ya Bin Zhao, Ming Jin Fan, Wei Min Liu, Yong Min Liang

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

A copper(I)-catalyzed three-component reaction to form (1-substituted-1H-1, 2,3-triazol-4-ylmethyl)-dialkylamines based on the Huisgen cycloaddition using amine, propargyl halide and azide in water was proposed. The process showed considerable synthetic advantages in terms of high atom economy, low environmental impact, atmospheric oxygen, wide substrate scope, mild reaction condition and good yields.

Original language	English
Pages (from-to)	9331-9337
Number of pages	7
Journal	Tetrahedron
Volume	61
Issue number	39
DOIs	https://doi.org/10.1016/j.tet.2005.07.060
State	Published - 26 Sep 2005
Externally published	Yes

Keywords

Copper(I)-catalyzed
Huisgen cycloaddition
Three-component reaction
Water

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10.1016/j.tet.2005.07.060

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abstract = "A copper(I)-catalyzed three-component reaction to form (1-substituted-1H-1, 2,3-triazol-4-ylmethyl)-dialkylamines based on the Huisgen cycloaddition using amine, propargyl halide and azide in water was proposed. The process showed considerable synthetic advantages in terms of high atom economy, low environmental impact, atmospheric oxygen, wide substrate scope, mild reaction condition and good yields.",

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author = "Yan, {Ze Yi} and Zhao, {Ya Bin} and Fan, {Ming Jin} and Liu, {Wei Min} and Liang, {Yong Min}",

year = "2005",

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T1 - General synthesis of (1-substituted-1H-1,2,3-triazol-4-ylmethyl)- dialkylamines via a copper(I)-catalyzed three-component reaction in water

AU - Yan, Ze Yi

AU - Zhao, Ya Bin

AU - Fan, Ming Jin

AU - Liu, Wei Min

AU - Liang, Yong Min

PY - 2005/9/26

Y1 - 2005/9/26

N2 - A copper(I)-catalyzed three-component reaction to form (1-substituted-1H-1, 2,3-triazol-4-ylmethyl)-dialkylamines based on the Huisgen cycloaddition using amine, propargyl halide and azide in water was proposed. The process showed considerable synthetic advantages in terms of high atom economy, low environmental impact, atmospheric oxygen, wide substrate scope, mild reaction condition and good yields.

AB - A copper(I)-catalyzed three-component reaction to form (1-substituted-1H-1, 2,3-triazol-4-ylmethyl)-dialkylamines based on the Huisgen cycloaddition using amine, propargyl halide and azide in water was proposed. The process showed considerable synthetic advantages in terms of high atom economy, low environmental impact, atmospheric oxygen, wide substrate scope, mild reaction condition and good yields.

KW - Copper(I)-catalyzed

KW - Huisgen cycloaddition

KW - Three-component reaction

KW - Water

UR - http://www.scopus.com/inward/record.url?scp=23944462604&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2005.07.060

DO - 10.1016/j.tet.2005.07.060

M3 - 文章

AN - SCOPUS:23944462604

SN - 0040-4020

VL - 61

SP - 9331

EP - 9337

JO - Tetrahedron

JF - Tetrahedron

IS - 39

ER -

General synthesis of (1-substituted-1H-1,2,3-triazol-4-ylmethyl)- dialkylamines via a copper(I)-catalyzed three-component reaction in water

Abstract

Keywords

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