FTCluster: Efficient mining fault-tolerant biclusters in microarray dataset

Miao Wang, Xuequn Shang, Miao Miao, Zhanhuai Li, Wenbin Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

8 Scopus citations

Abstract

Biclustering is a popular method for microarray dataset analysis. It allows for condition set and gene set points clustering simultaneously. However, the noisy data in microarray may disturb the mining results. In order to reduce the influence of noise and find more biological biclusters, we propose an algorithm, FTCluster, to mine fault-tolerant biclusters in microarray dataset. Unlike traditional fault-tolerant biclusters mining algorithms, FTCluster uses several novel techniques to improve the efficiency. It also adopts several techniques to generate relaxed biclusters without candidate maintenance. The experimental results show FTCluster is more effective than traditional algorithms. The biological significance of FTCluster is evaluated by Gene Ontology and the results show FTCluster can find larger biological relevant biclusters.

Original languageEnglish
Title of host publicationProceedings - 11th IEEE International Conference on Data Mining Workshops, ICDMW 2011
Pages1075-1082
Number of pages8
DOIs
StatePublished - 2011
Event11th IEEE International Conference on Data Mining Workshops, ICDMW 2011 - Vancouver, BC, Canada
Duration: 11 Dec 201111 Dec 2011

Publication series

NameProceedings - IEEE International Conference on Data Mining, ICDM
ISSN (Print)1550-4786

Conference

Conference11th IEEE International Conference on Data Mining Workshops, ICDMW 2011
Country/TerritoryCanada
CityVancouver, BC
Period11/12/1111/12/11

Keywords

  • Biclustering
  • Fault-tolerant bicluster
  • Gene expression
  • Microarray

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