TY - JOUR
T1 - Flexible bioelectrodes with enhanced wrinkle microstructures for reliable electrochemical modification and neuromodulation in vivo
AU - Ji, Bowen
AU - Wang, Minghao
AU - Ge, Chaofan
AU - Xie, Zhaoqian
AU - Guo, Zhejun
AU - Hong, Wen
AU - Gu, Xiaowei
AU - Wang, Longchun
AU - Yi, Zhiran
AU - Jiang, Chunpeng
AU - Yang, Bin
AU - Wang, Xiaolin
AU - Li, Xiuyan
AU - Li, Chengyu
AU - Liu, Jingquan
N1 - Publisher Copyright:
© 2019
PY - 2019/6/15
Y1 - 2019/6/15
N2 - Limited electrode size with high electrochemical performance and reliability of modified materials are two of the main concerns for flexible neural electrodes in recent years. Here, an effective fabrication method of enhanced micro-scale wrinkles based on oil-pretreated hyperelastic substrates (PDMS and Ecoflex) is proposed for the application of microelectrode biosensors. Compared to pre-stretching or compressing methods, this approach has better advantages including compatibility with MEMS processes on wafer and easy replication. Wrinkled gold microelectrodes exhibit superior electrochemical properties than the flat one, and no crack or delamination occurs after electroplating PEDOT:PSS and platinum black on wrinkled microelectrodes. Cyclic voltammetry (CV) scanning for 2500 times is performed to investigate adhesion and stability of modified materials. For the modified microelectrodes, no significant change is observed in charge storage capacity (CSC) and impedance at 1 kHz, whereas PEDOT:PSS coated flat microelectrodes appears delamination. Ultrasonication and cycling forces are also conducted on modified microelectrodes, which demonstrates little influence on the wrinkled ones. Flexible wrinkled microelectrodes are further verified by in-vivo ECoG recordings combined with optogenetics in mice. These results highlight the importance of micro-structure in neural electrode design and tremendous application potentials in flexible electronics.
AB - Limited electrode size with high electrochemical performance and reliability of modified materials are two of the main concerns for flexible neural electrodes in recent years. Here, an effective fabrication method of enhanced micro-scale wrinkles based on oil-pretreated hyperelastic substrates (PDMS and Ecoflex) is proposed for the application of microelectrode biosensors. Compared to pre-stretching or compressing methods, this approach has better advantages including compatibility with MEMS processes on wafer and easy replication. Wrinkled gold microelectrodes exhibit superior electrochemical properties than the flat one, and no crack or delamination occurs after electroplating PEDOT:PSS and platinum black on wrinkled microelectrodes. Cyclic voltammetry (CV) scanning for 2500 times is performed to investigate adhesion and stability of modified materials. For the modified microelectrodes, no significant change is observed in charge storage capacity (CSC) and impedance at 1 kHz, whereas PEDOT:PSS coated flat microelectrodes appears delamination. Ultrasonication and cycling forces are also conducted on modified microelectrodes, which demonstrates little influence on the wrinkled ones. Flexible wrinkled microelectrodes are further verified by in-vivo ECoG recordings combined with optogenetics in mice. These results highlight the importance of micro-structure in neural electrode design and tremendous application potentials in flexible electronics.
KW - ECoG recording
KW - Electrochemical modification
KW - Enhanced wrinkle microstructures
KW - Flexible bioelectrodes
KW - Optogenetics stimulation
UR - http://www.scopus.com/inward/record.url?scp=85064486067&partnerID=8YFLogxK
U2 - 10.1016/j.bios.2019.04.025
DO - 10.1016/j.bios.2019.04.025
M3 - 文章
C2 - 31022595
AN - SCOPUS:85064486067
SN - 0956-5663
VL - 135
SP - 181
EP - 191
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
ER -