Facile construction of shape-regulated β-cyclodextrin-based supramolecular self-assemblies for drug delivery

Yang Bai, Na An, Di Chen, Ying zhe Liu, Cai ping Liu, Hao Yao, Chao Wang, Xin Song, Wei Tian

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Although supramolecular prodrug self-assemblies have been proven as efficient nanocarriers for cancer therapy, tedious synthesis procedures have made their practical applications more difficult. In this paper, β-cyclodextrin-based supramolecular self-assemblies (SSAs) were directly constructed by utilizing β-cyclodextrin trimer (β-CD3) as the host unit and unmodified curcumin as the guest unit. Due to the adjustment of host-guest inclusion and hydrophilic-hydrophobic interactions occurring in the SSAs, their morphology could be readily tuned by changing the ratio of the two components. Different self-assembly morphologies, such as spherical complex micelles, spindle-like complex micelles and multi-compartment vesicles, were obtained. Furthermore, basic cell experiments were performed to study the corresponding effects of the SSA shape on their biological properties. Compared to the other micelles, the spindle-like complex micelles exhibited enhanced cellular toxicity, uptake behaviors and apoptosis rates, and the spherical complex micelles exhibited poor performance. The performance of the multi-compartment vesicles was similar to that of the spindle-like complex micelles. The facile construction of these shape-regulated SSAs and their different cellular biological properties might be valuable in the controlled drug release field.

Original languageEnglish
Article number115714
JournalCarbohydrate Polymers
Volume231
DOIs
StatePublished - 1 Mar 2020

Keywords

  • Drug delivery
  • Host-guest interaction
  • β-cyclodextrin

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