TY - JOUR
T1 - Facile construction of shape-regulated β-cyclodextrin-based supramolecular self-assemblies for drug delivery
AU - Bai, Yang
AU - An, Na
AU - Chen, Di
AU - Liu, Ying zhe
AU - Liu, Cai ping
AU - Yao, Hao
AU - Wang, Chao
AU - Song, Xin
AU - Tian, Wei
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Although supramolecular prodrug self-assemblies have been proven as efficient nanocarriers for cancer therapy, tedious synthesis procedures have made their practical applications more difficult. In this paper, β-cyclodextrin-based supramolecular self-assemblies (SSAs) were directly constructed by utilizing β-cyclodextrin trimer (β-CD3) as the host unit and unmodified curcumin as the guest unit. Due to the adjustment of host-guest inclusion and hydrophilic-hydrophobic interactions occurring in the SSAs, their morphology could be readily tuned by changing the ratio of the two components. Different self-assembly morphologies, such as spherical complex micelles, spindle-like complex micelles and multi-compartment vesicles, were obtained. Furthermore, basic cell experiments were performed to study the corresponding effects of the SSA shape on their biological properties. Compared to the other micelles, the spindle-like complex micelles exhibited enhanced cellular toxicity, uptake behaviors and apoptosis rates, and the spherical complex micelles exhibited poor performance. The performance of the multi-compartment vesicles was similar to that of the spindle-like complex micelles. The facile construction of these shape-regulated SSAs and their different cellular biological properties might be valuable in the controlled drug release field.
AB - Although supramolecular prodrug self-assemblies have been proven as efficient nanocarriers for cancer therapy, tedious synthesis procedures have made their practical applications more difficult. In this paper, β-cyclodextrin-based supramolecular self-assemblies (SSAs) were directly constructed by utilizing β-cyclodextrin trimer (β-CD3) as the host unit and unmodified curcumin as the guest unit. Due to the adjustment of host-guest inclusion and hydrophilic-hydrophobic interactions occurring in the SSAs, their morphology could be readily tuned by changing the ratio of the two components. Different self-assembly morphologies, such as spherical complex micelles, spindle-like complex micelles and multi-compartment vesicles, were obtained. Furthermore, basic cell experiments were performed to study the corresponding effects of the SSA shape on their biological properties. Compared to the other micelles, the spindle-like complex micelles exhibited enhanced cellular toxicity, uptake behaviors and apoptosis rates, and the spherical complex micelles exhibited poor performance. The performance of the multi-compartment vesicles was similar to that of the spindle-like complex micelles. The facile construction of these shape-regulated SSAs and their different cellular biological properties might be valuable in the controlled drug release field.
KW - Drug delivery
KW - Host-guest interaction
KW - β-cyclodextrin
UR - http://www.scopus.com/inward/record.url?scp=85076373606&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2019.115714
DO - 10.1016/j.carbpol.2019.115714
M3 - 文章
C2 - 31888845
AN - SCOPUS:85076373606
SN - 0144-8617
VL - 231
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
M1 - 115714
ER -