Fabrication of thermosensitive, star-shaped poly(L-lactide)-block-poly(N-isopropylacrylamide) copolymers with porphyrin core for photodynamic therapy

Xiao Hui Dai; Hua Jin; Mei Hong Cai; Hao Wang; Zhi Ping Zhou; Jian Ming Pan; Xiao Hong Wang; Yong Sheng Yan; Dong Ming Liu; Lin Sun

doi:10.1016/j.reactfunctpolym.2015.02.002

Fabrication of thermosensitive, star-shaped poly(L-lactide)-block-poly(N-isopropylacrylamide) copolymers with porphyrin core for photodynamic therapy

Xiao Hui Dai, Hua Jin, Mei Hong Cai, Hao Wang, Zhi Ping Zhou, Jian Ming Pan, Xiao Hong Wang, Yong Sheng Yan, Dong Ming Liu, Lin Sun

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Thermosensitive, star-shaped porphyrin-cored poly(L-lactide)-block-poly(N-isopropylacrylamide) (SPPLA-PNIPAM) was synthesized via ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer polymerization (RAFT). The composition and properties of copolymer were discussed based on the results of NMR, IR and GPC. With PNIPAM block length decreasing, the morphology of SPPLA-PNIPAM copolymer in aqueous solution transformed hierarchically from spherical micelles through wormlike micelles to vesicles, and the lower critical solution temperatures (LCST) of the copolymer solutions were determined to be 37.9°, 37.2°, 35.9°, respectively. The in vitro study indicated that SPPLA-PNIPAM showed no significant dark cytotoxicity at concentrations up to 128 μg/mL, while showed apparent phototoxicity toward BEL-7402 cancer cells. Considering a high singlet oxygen quantum yield and suitable nominal physiologic LCST, it is expected that the SPPLA-PNIPAM copolymer is a promising stimulus-responsive candidate which has a potential application in photodynamic therapy (PDT).

Original language	English
Pages (from-to)	9-17
Number of pages	9
Journal	Reactive and Functional Polymers
Volume	89
DOIs	https://doi.org/10.1016/j.reactfunctpolym.2015.02.002
State	Published - Apr 2015
Externally published	Yes

Keywords

PDT
Porphyrin
RAFT
Star-shaped
Thermosensitive

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.reactfunctpolym.2015.02.002

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Dai, X. H., Jin, H., Cai, M. H., Wang, H., Zhou, Z. P., Pan, J. M., Wang, X. H., Yan, Y. S., Liu, D. M., & Sun, L. (2015). Fabrication of thermosensitive, star-shaped poly(L-lactide)-block-poly(N-isopropylacrylamide) copolymers with porphyrin core for photodynamic therapy. Reactive and Functional Polymers, 89, 9-17. https://doi.org/10.1016/j.reactfunctpolym.2015.02.002

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title = "Fabrication of thermosensitive, star-shaped poly(L-lactide)-block-poly(N-isopropylacrylamide) copolymers with porphyrin core for photodynamic therapy",

abstract = "Thermosensitive, star-shaped porphyrin-cored poly(L-lactide)-block-poly(N-isopropylacrylamide) (SPPLA-PNIPAM) was synthesized via ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer polymerization (RAFT). The composition and properties of copolymer were discussed based on the results of NMR, IR and GPC. With PNIPAM block length decreasing, the morphology of SPPLA-PNIPAM copolymer in aqueous solution transformed hierarchically from spherical micelles through wormlike micelles to vesicles, and the lower critical solution temperatures (LCST) of the copolymer solutions were determined to be 37.9°, 37.2°, 35.9°, respectively. The in vitro study indicated that SPPLA-PNIPAM showed no significant dark cytotoxicity at concentrations up to 128 μg/mL, while showed apparent phototoxicity toward BEL-7402 cancer cells. Considering a high singlet oxygen quantum yield and suitable nominal physiologic LCST, it is expected that the SPPLA-PNIPAM copolymer is a promising stimulus-responsive candidate which has a potential application in photodynamic therapy (PDT).",

keywords = "PDT, Porphyrin, RAFT, Star-shaped, Thermosensitive",

author = "Dai, {Xiao Hui} and Hua Jin and Cai, {Mei Hong} and Hao Wang and Zhou, {Zhi Ping} and Pan, {Jian Ming} and Wang, {Xiao Hong} and Yan, {Yong Sheng} and Liu, {Dong Ming} and Lin Sun",

year = "2015",

month = apr,

doi = "10.1016/j.reactfunctpolym.2015.02.002",

language = "英语",

volume = "89",

pages = "9--17",

journal = "Reactive and Functional Polymers",

issn = "1381-5148",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Fabrication of thermosensitive, star-shaped poly(L-lactide)-block-poly(N-isopropylacrylamide) copolymers with porphyrin core for photodynamic therapy

AU - Dai, Xiao Hui

AU - Jin, Hua

AU - Cai, Mei Hong

AU - Wang, Hao

AU - Zhou, Zhi Ping

AU - Pan, Jian Ming

AU - Wang, Xiao Hong

AU - Yan, Yong Sheng

AU - Liu, Dong Ming

AU - Sun, Lin

PY - 2015/4

Y1 - 2015/4

N2 - Thermosensitive, star-shaped porphyrin-cored poly(L-lactide)-block-poly(N-isopropylacrylamide) (SPPLA-PNIPAM) was synthesized via ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer polymerization (RAFT). The composition and properties of copolymer were discussed based on the results of NMR, IR and GPC. With PNIPAM block length decreasing, the morphology of SPPLA-PNIPAM copolymer in aqueous solution transformed hierarchically from spherical micelles through wormlike micelles to vesicles, and the lower critical solution temperatures (LCST) of the copolymer solutions were determined to be 37.9°, 37.2°, 35.9°, respectively. The in vitro study indicated that SPPLA-PNIPAM showed no significant dark cytotoxicity at concentrations up to 128 μg/mL, while showed apparent phototoxicity toward BEL-7402 cancer cells. Considering a high singlet oxygen quantum yield and suitable nominal physiologic LCST, it is expected that the SPPLA-PNIPAM copolymer is a promising stimulus-responsive candidate which has a potential application in photodynamic therapy (PDT).

AB - Thermosensitive, star-shaped porphyrin-cored poly(L-lactide)-block-poly(N-isopropylacrylamide) (SPPLA-PNIPAM) was synthesized via ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer polymerization (RAFT). The composition and properties of copolymer were discussed based on the results of NMR, IR and GPC. With PNIPAM block length decreasing, the morphology of SPPLA-PNIPAM copolymer in aqueous solution transformed hierarchically from spherical micelles through wormlike micelles to vesicles, and the lower critical solution temperatures (LCST) of the copolymer solutions were determined to be 37.9°, 37.2°, 35.9°, respectively. The in vitro study indicated that SPPLA-PNIPAM showed no significant dark cytotoxicity at concentrations up to 128 μg/mL, while showed apparent phototoxicity toward BEL-7402 cancer cells. Considering a high singlet oxygen quantum yield and suitable nominal physiologic LCST, it is expected that the SPPLA-PNIPAM copolymer is a promising stimulus-responsive candidate which has a potential application in photodynamic therapy (PDT).

KW - PDT

KW - Porphyrin

KW - RAFT

KW - Star-shaped

KW - Thermosensitive

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U2 - 10.1016/j.reactfunctpolym.2015.02.002

DO - 10.1016/j.reactfunctpolym.2015.02.002

M3 - 文章

AN - SCOPUS:84925448099

SN - 1381-5148

VL - 89

SP - 9

EP - 17

JO - Reactive and Functional Polymers

JF - Reactive and Functional Polymers

ER -

Fabrication of thermosensitive, star-shaped poly(L-lactide)-block-poly(N-isopropylacrylamide) copolymers with porphyrin core for photodynamic therapy

Abstract

Keywords

UN SDGs

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