TY - JOUR
T1 - Enhanced mechanical properties and biological responses of SLA 3D printed biphasic calcium phosphate bioceramics by doping bioactive metal elements
AU - Dong, Dong
AU - Su, Haijun
AU - Li, Xiang
AU - Liu, Yuan
AU - Shen, Zhonglin
AU - Zhao, Di
AU - Guo, Yinuo
AU - Zhang, Zhuo
AU - Ren, Wei
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/8
Y1 - 2023/8
N2 - Favorable mechanical properties and outstanding bioactivity are necessary for bioceramics used for bone defect repair. The doping of Mg2+ and Fe3+ can improve the mechanical properties and bone regeneration capacity of calcium phosphate ceramics. In this study, magnesia oxide (MgO), ferric oxide (Fe2O3), and iron (Fe) powders are chosen as dopants to enhance biphasic calcium phosphate (BCP) bioceramics, and the MgO-BCP, Fe2O3-BCP, Fe-BCP bioceramics are prepared by stereolithography (SLA) for the first time. The effects of these dopants on the curing behavior of bioceramic slurries, mechanical properties, biodegradation, and cytocompatibility of BCP bioceramics are studied. The addition of 1 wt% Fe well enhances the flexural strength of BCP from 91.61 MPa to 122.60 MPa sintered at 1250 °C. The addition of 1 wt% MgO effectively promotes the biodegradation of BCP in simulated body solution (SBF), and enhances the proliferation of mouse pre-osteoblast (MC3T3-E1) cells in vitro. In addition, Fe powder is more suitable as a dopant for SLA 3D printed BCP than Fe2O3 powder, and all the performances of Fe-BCP are better than those of Fe2O3-BCP. The less microstructure defects and slower Fe3+ release rate make Fe-BCP have higher flexural strength and less cytotoxic compared with Fe2O3-BCP. This novel way exhibits beneficial effects of bioactive metal elements on mechanical properties and bioactivity, and indicates SLA 3D printed BCP bioceramic doped with MgO, Fe can be promising candidates for bone defect repair.
AB - Favorable mechanical properties and outstanding bioactivity are necessary for bioceramics used for bone defect repair. The doping of Mg2+ and Fe3+ can improve the mechanical properties and bone regeneration capacity of calcium phosphate ceramics. In this study, magnesia oxide (MgO), ferric oxide (Fe2O3), and iron (Fe) powders are chosen as dopants to enhance biphasic calcium phosphate (BCP) bioceramics, and the MgO-BCP, Fe2O3-BCP, Fe-BCP bioceramics are prepared by stereolithography (SLA) for the first time. The effects of these dopants on the curing behavior of bioceramic slurries, mechanical properties, biodegradation, and cytocompatibility of BCP bioceramics are studied. The addition of 1 wt% Fe well enhances the flexural strength of BCP from 91.61 MPa to 122.60 MPa sintered at 1250 °C. The addition of 1 wt% MgO effectively promotes the biodegradation of BCP in simulated body solution (SBF), and enhances the proliferation of mouse pre-osteoblast (MC3T3-E1) cells in vitro. In addition, Fe powder is more suitable as a dopant for SLA 3D printed BCP than Fe2O3 powder, and all the performances of Fe-BCP are better than those of Fe2O3-BCP. The less microstructure defects and slower Fe3+ release rate make Fe-BCP have higher flexural strength and less cytotoxic compared with Fe2O3-BCP. This novel way exhibits beneficial effects of bioactive metal elements on mechanical properties and bioactivity, and indicates SLA 3D printed BCP bioceramic doped with MgO, Fe can be promising candidates for bone defect repair.
KW - Bioceramics
KW - Biphasic calcium phosphate
KW - Dopants
KW - SLA 3D printing
UR - http://www.scopus.com/inward/record.url?scp=85150353576&partnerID=8YFLogxK
U2 - 10.1016/j.jeurceramsoc.2023.03.007
DO - 10.1016/j.jeurceramsoc.2023.03.007
M3 - 文章
AN - SCOPUS:85150353576
SN - 0955-2219
VL - 43
SP - 4167
EP - 4178
JO - Journal of the European Ceramic Society
JF - Journal of the European Ceramic Society
IS - 9
ER -