TY - JOUR
T1 - Electron Beam Melting Fabrication of Porous Ti6Al4V Scaffolds
T2 - Cytocompatibility and Osteogenesis
AU - Lv, Jia
AU - Jia, Zhaojun
AU - Li, Jing
AU - Wang, Yanen
AU - Yang, Jun
AU - Xiu, Peng
AU - Zhang, Ke
AU - Cai, Hong
AU - Liu, Zhongjun
N1 - Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Titanium-based implants possessing adequately low elasticity modulus and customdesigned structures are urgently demanded in recent years for orthopedic applications. Electron beam melting (EBM) provides an opportunity to fabricated porous titanium scaffolds that meet the as-mentioned requirements, and it further allows for improved bone regeneration and increased contact area at implant-tissue interface. As a novel additive manufacturing (AM) technique, EBM could conveniently produce scaffolds with tunable porosity and shapes and complex structures based on the popular "bottom-up" concept. In the present work, EBM-produced Ti6Al4V cylinders designed with either a small pore size (EBMS, 640 μm) or a large one (EBML, 1200 μm) were characterized in respect of microstructure, permeability and specific surface area, and their cytocompatibility and osteogenic ability were evaluated subsequently in vitro. Both samples EBMS and EBML could support the attachment and proliferation of hMSCs with minimal inflammatory cytokines secretion. The EBMS scaffolds were relatively more compatible with hMSCs than the EBML and they better sustained osteogenesis probably for their larger specific surface area.
AB - Titanium-based implants possessing adequately low elasticity modulus and customdesigned structures are urgently demanded in recent years for orthopedic applications. Electron beam melting (EBM) provides an opportunity to fabricated porous titanium scaffolds that meet the as-mentioned requirements, and it further allows for improved bone regeneration and increased contact area at implant-tissue interface. As a novel additive manufacturing (AM) technique, EBM could conveniently produce scaffolds with tunable porosity and shapes and complex structures based on the popular "bottom-up" concept. In the present work, EBM-produced Ti6Al4V cylinders designed with either a small pore size (EBMS, 640 μm) or a large one (EBML, 1200 μm) were characterized in respect of microstructure, permeability and specific surface area, and their cytocompatibility and osteogenic ability were evaluated subsequently in vitro. Both samples EBMS and EBML could support the attachment and proliferation of hMSCs with minimal inflammatory cytokines secretion. The EBMS scaffolds were relatively more compatible with hMSCs than the EBML and they better sustained osteogenesis probably for their larger specific surface area.
UR - http://www.scopus.com/inward/record.url?scp=84942505701&partnerID=8YFLogxK
U2 - 10.1002/adem.201400508
DO - 10.1002/adem.201400508
M3 - 文章
AN - SCOPUS:84942505701
SN - 1438-1656
VL - 17
SP - 1391
EP - 1398
JO - Advanced Engineering Materials
JF - Advanced Engineering Materials
IS - 9
ER -