Effect of surface roughness of carbon/carbon composites on osteoblasts growth behaviour

Lei Lei Zhang, He Jun Li, Ke Zhi Li, Xin Tao Li, Yan Qiang Zhai, Yu Lei Zhang

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The aim of this study is to investigate the role of surface roughness of carbon/carbon (C/C) composites on osteoblasts morphology, adhesion and proliferation. C/C composites were prepared by chemical vapor infiltration and three different values of surface roughness were created by treatment with two kinds of grinding paper and mechanical polishing. The surface roughness of C/C composites was measured by Talysurf profilometer, and cell culture was performed with MG-63 osteoblasts. The adhesion rate, morphology and proliferation rate were assessed. The results show that the adhesion rate increase and the proliferation rate decrease with the increase of roughness. The orientation of the osteoblasts is affected by the roughness, the higher the roughness, the greater the effect. As surface roughness increasing, the morphology of the osteoblasts changes from shuttle and strip shape to slice shape.

Original languageEnglish
Pages (from-to)341-345
Number of pages5
JournalWuji Cailiao Xuebao/Journal of Inorganic Materials
Volume23
Issue number2
DOIs
StatePublished - Mar 2008

Keywords

  • Carbon/carbon composites
  • Osteoblasts
  • Roughness

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