Effect of 2-(3-carboxy-1-oxopropyl) amino-2-deoxy-D-glucose on human esophageal cancer cell line

Jing Wu; Hong Lu; Yun Zhou; Liang Qiao; Rui Ji; Ai Qing Wang; Wei Min Liu; Qun Ji Xue

doi:10.3748/wjg.v10.i22.3380

Effect of 2-(3-carboxy-1-oxopropyl) amino-2-deoxy-D-glucose on human esophageal cancer cell line

Jing Wu, Hong Lu, Yun Zhou, Liang Qiao, Rui Ji, Ai Qing Wang, Wei Min Liu, Qun Ji Xue

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Aim: To determine whether 2-(3-carboxy-1-oxopropy1) amino-2-deoxy-D-glucose (COPADG), a derivative of D-amino-glucose, inhibited the growth of human esophageal cancer cell line Eca-109. Methods: Effects of COPADG on Eca-109 cells cultured in RPMI 1640 medium were examined by a tetrazolium-based colorimetric assay (MTT assay). Results: COPADG inhibited the growth of Eca-109 cells in a dose- and time-dependent manner; the maximum inhibition rate was 83.75%. Conclusion: COPADG can directly inhibit the proliferation of Eca-109 cells, which may serve as the experimental evidence for development of new drugs for esophageal cancer therapy.

Original language	English
Pages (from-to)	3380-3381
Number of pages	2
Journal	World Journal of Gastroenterology
Volume	10
Issue number	22
DOIs	https://doi.org/10.3748/wjg.v10.i22.3380
State	Published - 15 Nov 2004
Externally published	Yes

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@article{ae96d20f08d745ce9a3d653263235444,

title = "Effect of 2-(3-carboxy-1-oxopropyl) amino-2-deoxy-D-glucose on human esophageal cancer cell line",

abstract = "Aim: To determine whether 2-(3-carboxy-1-oxopropy1) amino-2-deoxy-D-glucose (COPADG), a derivative of D-amino-glucose, inhibited the growth of human esophageal cancer cell line Eca-109. Methods: Effects of COPADG on Eca-109 cells cultured in RPMI 1640 medium were examined by a tetrazolium-based colorimetric assay (MTT assay). Results: COPADG inhibited the growth of Eca-109 cells in a dose- and time-dependent manner; the maximum inhibition rate was 83.75%. Conclusion: COPADG can directly inhibit the proliferation of Eca-109 cells, which may serve as the experimental evidence for development of new drugs for esophageal cancer therapy.",

author = "Jing Wu and Hong Lu and Yun Zhou and Liang Qiao and Rui Ji and Wang, {Ai Qing} and Liu, {Wei Min} and Xue, {Qun Ji}",

year = "2004",

month = nov,

day = "15",

doi = "10.3748/wjg.v10.i22.3380",

language = "英语",

volume = "10",

pages = "3380--3381",

journal = "World Journal of Gastroenterology",

issn = "1007-9327",

publisher = "Baishideng Publishing Group Inc",

number = "22",

}

TY - JOUR

T1 - Effect of 2-(3-carboxy-1-oxopropyl) amino-2-deoxy-D-glucose on human esophageal cancer cell line

AU - Wu, Jing

AU - Lu, Hong

AU - Zhou, Yun

AU - Qiao, Liang

AU - Ji, Rui

AU - Wang, Ai Qing

AU - Liu, Wei Min

AU - Xue, Qun Ji

PY - 2004/11/15

Y1 - 2004/11/15

N2 - Aim: To determine whether 2-(3-carboxy-1-oxopropy1) amino-2-deoxy-D-glucose (COPADG), a derivative of D-amino-glucose, inhibited the growth of human esophageal cancer cell line Eca-109. Methods: Effects of COPADG on Eca-109 cells cultured in RPMI 1640 medium were examined by a tetrazolium-based colorimetric assay (MTT assay). Results: COPADG inhibited the growth of Eca-109 cells in a dose- and time-dependent manner; the maximum inhibition rate was 83.75%. Conclusion: COPADG can directly inhibit the proliferation of Eca-109 cells, which may serve as the experimental evidence for development of new drugs for esophageal cancer therapy.

AB - Aim: To determine whether 2-(3-carboxy-1-oxopropy1) amino-2-deoxy-D-glucose (COPADG), a derivative of D-amino-glucose, inhibited the growth of human esophageal cancer cell line Eca-109. Methods: Effects of COPADG on Eca-109 cells cultured in RPMI 1640 medium were examined by a tetrazolium-based colorimetric assay (MTT assay). Results: COPADG inhibited the growth of Eca-109 cells in a dose- and time-dependent manner; the maximum inhibition rate was 83.75%. Conclusion: COPADG can directly inhibit the proliferation of Eca-109 cells, which may serve as the experimental evidence for development of new drugs for esophageal cancer therapy.

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U2 - 10.3748/wjg.v10.i22.3380

DO - 10.3748/wjg.v10.i22.3380

M3 - 文章

C2 - 15484324

AN - SCOPUS:9744246737

SN - 1007-9327

VL - 10

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EP - 3381

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

IS - 22

ER -

Effect of 2-(3-carboxy-1-oxopropyl) amino-2-deoxy-D-glucose on human esophageal cancer cell line

Abstract

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