TY - JOUR
T1 - Dynamical alterations of brain function and gut microbiome in weight loss
AU - Zhou, Jing
AU - Wu, Xiaoling
AU - Xiang, Tianyuan
AU - Liu, Fei
AU - Gao, Hui
AU - Tong, Li
AU - Yan, Bin
AU - Li, Zhonglin
AU - Zhang, Chi
AU - Wang, Linyuan
AU - Ou, Lei
AU - Li, Zhongxia
AU - Wang, Wen
AU - Yang, Tingting
AU - Li, Fengyun
AU - Ma, Huimin
AU - Zhao, Xiaojuan
AU - Mi, Na
AU - Yu, Ziya
AU - Lan, Canhui
AU - Wang, Qi
AU - Li, Hao
AU - Wang, Liming
AU - Wang, Xiaoning
AU - Li, Yongli
AU - Zeng, Qiang
N1 - Publisher Copyright:
Copyright © 2023 Zhou, Wu, Xiang, Liu, Gao, Tong, Yan, Li, Zhang, Wang, Ou, Li, Wang, Yang, Li, Ma, Zhao, Mi, Yu, Lan, Wang, Li, Wang, Wang, Li and Zeng.
PY - 2023
Y1 - 2023
N2 - Objective: Intermittent energy restriction (IER) is an effective weight loss strategy. However, little is known about the dynamic effects of IER on the brain-gut-microbiome axis. Methods: In this study, a total of 25 obese individuals successfully lost weight after a 2-month IER intervention. FMRI was used to determine the activity of brain regions. Metagenomic sequencing was performed to identify differentially abundant gut microbes and pathways in from fecal samples. Results: Our results showed that IER longitudinally reduced the activity of obese-related brain regions at different timepoints, including the inferior frontal orbital gyrus in the cognitive control circuit, the putamen in the emotion and learning circuit, and the anterior cingulate cortex in the sensory circuit. IER longitudinally reduced E. coli abundance across multiple timepoints while elevating the abundance of obesity-related Faecalibacterium prausnitzii, Parabacteroides distasonis, and Bacterokles uniformis. Correlation analysis revealed longitudinally correlations between gut bacteria abundance alterations and brain activity changes. Conclusions: There was dynamical alteration of BGM axis (the communication of E. coli with specific brain regions) during the weight loss under the IER.
AB - Objective: Intermittent energy restriction (IER) is an effective weight loss strategy. However, little is known about the dynamic effects of IER on the brain-gut-microbiome axis. Methods: In this study, a total of 25 obese individuals successfully lost weight after a 2-month IER intervention. FMRI was used to determine the activity of brain regions. Metagenomic sequencing was performed to identify differentially abundant gut microbes and pathways in from fecal samples. Results: Our results showed that IER longitudinally reduced the activity of obese-related brain regions at different timepoints, including the inferior frontal orbital gyrus in the cognitive control circuit, the putamen in the emotion and learning circuit, and the anterior cingulate cortex in the sensory circuit. IER longitudinally reduced E. coli abundance across multiple timepoints while elevating the abundance of obesity-related Faecalibacterium prausnitzii, Parabacteroides distasonis, and Bacterokles uniformis. Correlation analysis revealed longitudinally correlations between gut bacteria abundance alterations and brain activity changes. Conclusions: There was dynamical alteration of BGM axis (the communication of E. coli with specific brain regions) during the weight loss under the IER.
KW - brain-gut-microbiome axis
KW - functional magnetic resonance imaging
KW - intermittent energy restriction
KW - metagenomics
KW - weight loss
UR - http://www.scopus.com/inward/record.url?scp=85181228368&partnerID=8YFLogxK
U2 - 10.3389/fcimb.2023.1269548
DO - 10.3389/fcimb.2023.1269548
M3 - 文章
C2 - 38173792
AN - SCOPUS:85181228368
SN - 2235-2988
VL - 13
JO - Frontiers in Cellular and Infection Microbiology
JF - Frontiers in Cellular and Infection Microbiology
M1 - 1269548
ER -
