TY - JOUR
T1 - Dual/Multi-responsive fluorogenic probes for multiple analytes in mitochondria
T2 - From design to applications
AU - Guo, Jiaying
AU - Fang, Bin
AU - Bai, Hua
AU - Wang, Limin
AU - Peng, Bo
AU - Qin, Xu Jun
AU - Fu, Li
AU - Yao, Chuanhao
AU - Li, Lin
AU - Huang, Wei
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/10
Y1 - 2022/10
N2 - As the “powerhouse” of the cells, mitochondria participate in numerous energy metabolism processes. Abnormal structure and function of mitochondria will affect the activities of living cell, leading to pathological changes including degenerative diseases, metabolic diseases, genetic diseases, and tumors. Early diagnosis and treatment of mitochondrial diseases are essential to improve the survival rate of patients. Therefore, rapid, sensitive and simultaneous detection of multiple analytes of mitochondrial diseases is of great importance for human health. In recent years, dual/multi-responsive fluorogenic probes (DMRFPs) with specific recognition functions and selective signal readout/conversion for analytes in mitochondria have been developed. In this review, we have summarized the recent advances in DMRFPs for analytes detection in mitochondria such as simultaneous detection of i) microenvironment and related analytes, ii) redox species and iii) other analytes in mitochondria and given a brief perspective on the design of DMRFPs and their applications to inspire the new generation of mitochondrial-targeting DMRFPs.
AB - As the “powerhouse” of the cells, mitochondria participate in numerous energy metabolism processes. Abnormal structure and function of mitochondria will affect the activities of living cell, leading to pathological changes including degenerative diseases, metabolic diseases, genetic diseases, and tumors. Early diagnosis and treatment of mitochondrial diseases are essential to improve the survival rate of patients. Therefore, rapid, sensitive and simultaneous detection of multiple analytes of mitochondrial diseases is of great importance for human health. In recent years, dual/multi-responsive fluorogenic probes (DMRFPs) with specific recognition functions and selective signal readout/conversion for analytes in mitochondria have been developed. In this review, we have summarized the recent advances in DMRFPs for analytes detection in mitochondria such as simultaneous detection of i) microenvironment and related analytes, ii) redox species and iii) other analytes in mitochondria and given a brief perspective on the design of DMRFPs and their applications to inspire the new generation of mitochondrial-targeting DMRFPs.
KW - Bioimaging
KW - Biomarkers
KW - Dual/Multi-responsive
KW - Fluorogenic probes
KW - Mitochondria
UR - http://www.scopus.com/inward/record.url?scp=85132394448&partnerID=8YFLogxK
U2 - 10.1016/j.trac.2022.116697
DO - 10.1016/j.trac.2022.116697
M3 - 文献综述
AN - SCOPUS:85132394448
SN - 0165-9936
VL - 155
JO - TrAC - Trends in Analytical Chemistry
JF - TrAC - Trends in Analytical Chemistry
M1 - 116697
ER -
