Crystalline structures of l-cysteine and l-cystine: a combined theoretical and experimental characterization

Yangyang Su; Etienne P. Hessou; Estefania Colombo; Gustavo Belletti; Ali Moussadik; Ivan T. Lucas; Vincent Frochot; Michel Daudon; Stéphan Rouzière; Dominique Bazin; Kezhi Li; Paola Quaino; Frederik Tielens

doi:10.1007/s00726-022-03144-6

Crystalline structures of l-cysteine and l-cystine: a combined theoretical and experimental characterization

Yangyang Su, Etienne P. Hessou, Estefania Colombo, Gustavo Belletti, Ali Moussadik, Ivan T. Lucas, Vincent Frochot, Michel Daudon, Stéphan Rouzière, Dominique Bazin, Kezhi Li, Paola Quaino, Frederik Tielens

School of Materials Sience and Engineering

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

It is assumed that genetic diseases affecting the metabolism of cysteine and the kidney function lead to two different kinds of pathologies, namely cystinuria and cystinosis whereby generate l-cystine crystals. Recently, the presence of l-cysteine crystal has been underlined in the case of cystinosis. Interestingly, it can be strikingly seen that cystine ([–S–CH₂–CH–(NH₂)–COOH]₂) consists of two cysteine (C₃H₇NO₂S) molecules connected by a disulfide (S–S) bond. Therefore, the study of cystine and cysteine is important for providing a better understanding of cystinuria and cystinosis. In this paper, we elucidate the discrepancy between l-cystine and l-cysteine by investigating the theoretical and experimental infrared spectra (IR), X-ray diffraction (XRD) as well as Raman spectra aiming to obtain a better characterization of abnormal deposits related to these two genetic pathologies.

Original language	English
Pages (from-to)	1123-1133
Number of pages	11
Journal	Amino Acids
Volume	54
Issue number	8
DOIs	https://doi.org/10.1007/s00726-022-03144-6
State	Published - Aug 2022

Keywords

Biominerals
Characterization
Computer simulations
Crystalline structure
l-cysteine
l-cystine

Access to Document

10.1007/s00726-022-03144-6

Cite this

@article{e3a0fde1d05d4a25b54fa02bf730e572,

title = "Crystalline structures of l-cysteine and l-cystine: a combined theoretical and experimental characterization",

abstract = "It is assumed that genetic diseases affecting the metabolism of cysteine and the kidney function lead to two different kinds of pathologies, namely cystinuria and cystinosis whereby generate l-cystine crystals. Recently, the presence of l-cysteine crystal has been underlined in the case of cystinosis. Interestingly, it can be strikingly seen that cystine ([–S–CH2–CH–(NH2)–COOH]2) consists of two cysteine (C3H7NO2S) molecules connected by a disulfide (S–S) bond. Therefore, the study of cystine and cysteine is important for providing a better understanding of cystinuria and cystinosis. In this paper, we elucidate the discrepancy between l-cystine and l-cysteine by investigating the theoretical and experimental infrared spectra (IR), X-ray diffraction (XRD) as well as Raman spectra aiming to obtain a better characterization of abnormal deposits related to these two genetic pathologies.",

keywords = "Biominerals, Characterization, Computer simulations, Crystalline structure, l-cysteine, l-cystine",

author = "Yangyang Su and Hessou, {Etienne P.} and Estefania Colombo and Gustavo Belletti and Ali Moussadik and Lucas, {Ivan T.} and Vincent Frochot and Michel Daudon and St{\'e}phan Rouzi{\`e}re and Dominique Bazin and Kezhi Li and Paola Quaino and Frederik Tielens",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.",

year = "2022",

month = aug,

doi = "10.1007/s00726-022-03144-6",

language = "英语",

volume = "54",

pages = "1123--1133",

journal = "Amino Acids",

issn = "0939-4451",

publisher = "Springer",

number = "8",

}

TY - JOUR

T1 - Crystalline structures of l-cysteine and l-cystine

T2 - a combined theoretical and experimental characterization

AU - Su, Yangyang

AU - Hessou, Etienne P.

AU - Colombo, Estefania

AU - Belletti, Gustavo

AU - Moussadik, Ali

AU - Lucas, Ivan T.

AU - Frochot, Vincent

AU - Daudon, Michel

AU - Rouzière, Stéphan

AU - Bazin, Dominique

AU - Li, Kezhi

AU - Quaino, Paola

AU - Tielens, Frederik

PY - 2022/8

Y1 - 2022/8

N2 - It is assumed that genetic diseases affecting the metabolism of cysteine and the kidney function lead to two different kinds of pathologies, namely cystinuria and cystinosis whereby generate l-cystine crystals. Recently, the presence of l-cysteine crystal has been underlined in the case of cystinosis. Interestingly, it can be strikingly seen that cystine ([–S–CH2–CH–(NH2)–COOH]2) consists of two cysteine (C3H7NO2S) molecules connected by a disulfide (S–S) bond. Therefore, the study of cystine and cysteine is important for providing a better understanding of cystinuria and cystinosis. In this paper, we elucidate the discrepancy between l-cystine and l-cysteine by investigating the theoretical and experimental infrared spectra (IR), X-ray diffraction (XRD) as well as Raman spectra aiming to obtain a better characterization of abnormal deposits related to these two genetic pathologies.

AB - It is assumed that genetic diseases affecting the metabolism of cysteine and the kidney function lead to two different kinds of pathologies, namely cystinuria and cystinosis whereby generate l-cystine crystals. Recently, the presence of l-cysteine crystal has been underlined in the case of cystinosis. Interestingly, it can be strikingly seen that cystine ([–S–CH2–CH–(NH2)–COOH]2) consists of two cysteine (C3H7NO2S) molecules connected by a disulfide (S–S) bond. Therefore, the study of cystine and cysteine is important for providing a better understanding of cystinuria and cystinosis. In this paper, we elucidate the discrepancy between l-cystine and l-cysteine by investigating the theoretical and experimental infrared spectra (IR), X-ray diffraction (XRD) as well as Raman spectra aiming to obtain a better characterization of abnormal deposits related to these two genetic pathologies.

KW - Biominerals

KW - Characterization

KW - Computer simulations

KW - Crystalline structure

KW - l-cysteine

KW - l-cystine

UR - http://www.scopus.com/inward/record.url?scp=85126332108&partnerID=8YFLogxK

U2 - 10.1007/s00726-022-03144-6

DO - 10.1007/s00726-022-03144-6

M3 - 文章

C2 - 35296914

AN - SCOPUS:85126332108

SN - 0939-4451

VL - 54

SP - 1123

EP - 1133

JO - Amino Acids

JF - Amino Acids

IS - 8

ER -

Crystalline structures of l-cysteine and l-cystine: a combined theoretical and experimental characterization

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this