TY - JOUR
T1 - Construction of β-cyclodextrin-based supramolecular hyperbranched polymers self-assemblies using AB 2 -type macromonomer and their application in the drug delivery field
AU - Bai, Yang
AU - Liu, Cai ping
AU - Xie, Fang yuan
AU - Ma, Ran
AU - Zhuo, Long hai
AU - Li, Na
AU - Tian, Wei
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Despite some efforts have been made in the research of supramolecular hyperbranched polymers (SHPs) self-assemblies, the study which has not been consideration to date is the influence of incoming stimuli-responsive polymer chain on their self-assembly property undergo outer stimuli. The introduction of stimuli-responsive segments which could maintain their hydrophilic property are expected to affect the self-assembly behaviour of SHPs and expand their further biomedical application. In this paper, AB 2 -type macromolecular monomer, LA-(CD-PDMA) 2 , which consisted one lithocholic acid (LA) and two β-cyclodextrin terminated poly(2-(dimethylamino)ethyl methacrylate) segments (CD-PDMA) was synthesized. LA-(CD-PDMA) 2 based SHP were obtained based on the host-guest inclusion interactions of CD/LA moietes and with PDMA as pH-responsive hydrophilic chains. As a control to study the influence of incoming PDMA chains, both LA-(CD-PDMA) 2 based SHPs-1 and LA-CD 2 based SHPs-2 self-assemblies were comparatively investiged through 2D 1 H NMR ROESY, transmission electron microscopy (TEM) and dynamic light scattering (DLS). The results suggested that except for the higher drug loading efficiency LA-(CD-PDMA) 2 based SHPs-1 pocessing, the release rates of SHPs-1 increased notably at pH 5.0 than that of pH 7.4 due to the repulsion and stretch of protonated PDMA chains while the release rates of SHPs-2 showed no obvious difference. Finally, basic cell experiments demonstrated that the SHPs based self-assemblies can be internalized into cancer cells, indicating their potential application in the drug delivery field.
AB - Despite some efforts have been made in the research of supramolecular hyperbranched polymers (SHPs) self-assemblies, the study which has not been consideration to date is the influence of incoming stimuli-responsive polymer chain on their self-assembly property undergo outer stimuli. The introduction of stimuli-responsive segments which could maintain their hydrophilic property are expected to affect the self-assembly behaviour of SHPs and expand their further biomedical application. In this paper, AB 2 -type macromolecular monomer, LA-(CD-PDMA) 2 , which consisted one lithocholic acid (LA) and two β-cyclodextrin terminated poly(2-(dimethylamino)ethyl methacrylate) segments (CD-PDMA) was synthesized. LA-(CD-PDMA) 2 based SHP were obtained based on the host-guest inclusion interactions of CD/LA moietes and with PDMA as pH-responsive hydrophilic chains. As a control to study the influence of incoming PDMA chains, both LA-(CD-PDMA) 2 based SHPs-1 and LA-CD 2 based SHPs-2 self-assemblies were comparatively investiged through 2D 1 H NMR ROESY, transmission electron microscopy (TEM) and dynamic light scattering (DLS). The results suggested that except for the higher drug loading efficiency LA-(CD-PDMA) 2 based SHPs-1 pocessing, the release rates of SHPs-1 increased notably at pH 5.0 than that of pH 7.4 due to the repulsion and stretch of protonated PDMA chains while the release rates of SHPs-2 showed no obvious difference. Finally, basic cell experiments demonstrated that the SHPs based self-assemblies can be internalized into cancer cells, indicating their potential application in the drug delivery field.
KW - Drug delivery
KW - Host-guest interactions
KW - Self-assembly behavior
KW - Supramolecular hyperbranched polymer
KW - β-Cyclodextrin
UR - http://www.scopus.com/inward/record.url?scp=85062726455&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2019.03.017
DO - 10.1016/j.carbpol.2019.03.017
M3 - 文章
C2 - 30879686
AN - SCOPUS:85062726455
SN - 0144-8617
VL - 213
SP - 411
EP - 418
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
ER -
