Concentration-dependent biphasic effects of resveratrol on human natural killer cells in vitro

Qi Li; Ting Huyan; Lin Jie Ye; Ji Li; Jun Ling Shi; Qing Sheng Huang

doi:10.1021/jf502950u

Concentration-dependent biphasic effects of resveratrol on human natural killer cells in vitro

Qi Li, Ting Huyan, Lin Jie Ye, Ji Li, Jun Ling Shi, Qing Sheng Huang

School of life sciences

Northwestern Polytechnical University Xian

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Resveratrol (RES) is a polyphenol phytoalexin from plants, which has been reported to possess a variety of biological effects. The properties of RES on human natural killer (NK) cells were assessed in this study. Results showed that RES has concentration-dependent biphasic effects on NK cells. In high concentration (50 μM), RES can inhibit viability and promoted apoptosis of NK cells and human lymphoblastoid T (Jurkat) cells, which may affect the caspase signaling pathway. The Jurkat cells were more sensitive than NK cells on the RES caused cell death. However, when the concentration range reduced from 3.13 to 1.56 μM, RES showed the positive effects on NK cells by increasing the NK cells cytotoxicity via up-regulating the expression of NKG2D and IFN-γ (in mRNA and protein levels). These results indicated that one needs to pay more attention to the dosage and biphasic effects when RES was applied as antitumor drugs or health products.

Original language	English
Pages (from-to)	10928-10935
Number of pages	8
Journal	Journal of Agricultural and Food Chemistry
Volume	62
Issue number	45
DOIs	https://doi.org/10.1021/jf502950u
State	Published - 12 Nov 2014

Keywords

apoptosis
caspase
cytotoxicity
human natural killer (NK) cells
resveratrol (RES)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/jf502950u

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title = "Concentration-dependent biphasic effects of resveratrol on human natural killer cells in vitro",

abstract = "Resveratrol (RES) is a polyphenol phytoalexin from plants, which has been reported to possess a variety of biological effects. The properties of RES on human natural killer (NK) cells were assessed in this study. Results showed that RES has concentration-dependent biphasic effects on NK cells. In high concentration (50 μM), RES can inhibit viability and promoted apoptosis of NK cells and human lymphoblastoid T (Jurkat) cells, which may affect the caspase signaling pathway. The Jurkat cells were more sensitive than NK cells on the RES caused cell death. However, when the concentration range reduced from 3.13 to 1.56 μM, RES showed the positive effects on NK cells by increasing the NK cells cytotoxicity via up-regulating the expression of NKG2D and IFN-γ (in mRNA and protein levels). These results indicated that one needs to pay more attention to the dosage and biphasic effects when RES was applied as antitumor drugs or health products.",

keywords = "apoptosis, caspase, cytotoxicity, human natural killer (NK) cells, resveratrol (RES)",

author = "Qi Li and Ting Huyan and Ye, {Lin Jie} and Ji Li and Shi, {Jun Ling} and Huang, {Qing Sheng}",

note = "Publisher Copyright: {\textcopyright} 2014 American Chemical Society.",

year = "2014",

month = nov,

day = "12",

doi = "10.1021/jf502950u",

language = "英语",

volume = "62",

pages = "10928--10935",

journal = "Journal of Agricultural and Food Chemistry",

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TY - JOUR

T1 - Concentration-dependent biphasic effects of resveratrol on human natural killer cells in vitro

AU - Li, Qi

AU - Huyan, Ting

AU - Ye, Lin Jie

AU - Li, Ji

AU - Shi, Jun Ling

AU - Huang, Qing Sheng

PY - 2014/11/12

Y1 - 2014/11/12

N2 - Resveratrol (RES) is a polyphenol phytoalexin from plants, which has been reported to possess a variety of biological effects. The properties of RES on human natural killer (NK) cells were assessed in this study. Results showed that RES has concentration-dependent biphasic effects on NK cells. In high concentration (50 μM), RES can inhibit viability and promoted apoptosis of NK cells and human lymphoblastoid T (Jurkat) cells, which may affect the caspase signaling pathway. The Jurkat cells were more sensitive than NK cells on the RES caused cell death. However, when the concentration range reduced from 3.13 to 1.56 μM, RES showed the positive effects on NK cells by increasing the NK cells cytotoxicity via up-regulating the expression of NKG2D and IFN-γ (in mRNA and protein levels). These results indicated that one needs to pay more attention to the dosage and biphasic effects when RES was applied as antitumor drugs or health products.

AB - Resveratrol (RES) is a polyphenol phytoalexin from plants, which has been reported to possess a variety of biological effects. The properties of RES on human natural killer (NK) cells were assessed in this study. Results showed that RES has concentration-dependent biphasic effects on NK cells. In high concentration (50 μM), RES can inhibit viability and promoted apoptosis of NK cells and human lymphoblastoid T (Jurkat) cells, which may affect the caspase signaling pathway. The Jurkat cells were more sensitive than NK cells on the RES caused cell death. However, when the concentration range reduced from 3.13 to 1.56 μM, RES showed the positive effects on NK cells by increasing the NK cells cytotoxicity via up-regulating the expression of NKG2D and IFN-γ (in mRNA and protein levels). These results indicated that one needs to pay more attention to the dosage and biphasic effects when RES was applied as antitumor drugs or health products.

KW - apoptosis

KW - caspase

KW - cytotoxicity

KW - human natural killer (NK) cells

KW - resveratrol (RES)

UR - http://www.scopus.com/inward/record.url?scp=84910115953&partnerID=8YFLogxK

U2 - 10.1021/jf502950u

DO - 10.1021/jf502950u

M3 - 文章

C2 - 25360711

AN - SCOPUS:84910115953

SN - 0021-8561

VL - 62

SP - 10928

EP - 10935

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

IS - 45

ER -

Concentration-dependent biphasic effects of resveratrol on human natural killer cells in vitro

Abstract

Keywords

UN SDGs

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