TY - JOUR
T1 - Combination Using Magnetic Iron Oxide Nanoparticles and Magnetic Field for Cancer Therapy
AU - Sun, Wenjun
AU - Chai, Xiaoxia
AU - Zhang, Yuan
AU - Yu, Tongyao
AU - Wang, Yuhua
AU - Zhao, Wenzhe
AU - Liu, Yanhua
AU - Yin, Dachuan
AU - Zhang, Chenyan
N1 - Publisher Copyright:
© 2024 The Chemical Society of Japan and Wiley-VCH GmbH.
PY - 2024/12
Y1 - 2024/12
N2 - Iron oxide nanoparticles (MNPs) demonstrate notable benefits in magnetic induction, attributed to their distinctive physical and chemical attributes. Emerging cancer treatment utilizing magnetic fields have also gathered increasing attention in the biomedical field. However, the defects of difficult dispersion and poor biocompatibility of MNPs seriously hinder their application. In order to overcome its inherent defects and maximize the therapeutic potential of MNPs, various functionalized MNPs have been developed, and numerous combined treatment methods based on MNPs have been widely studied. In this review, we compare and analyze the common nanoparticles based on MNPs with different sizes, shapes, and functional modifications. Additionally, we introduced the therapeutic mechanisms of the strategies, such as magnetically controlled targeting, magnetic hyperthermia, and magneto-mechanical effect, which based on the unique magnetic induction capabilities of MNPs. Finally, main challenges of MNPs as smart nanomaterials were also discussed. This review seeks to offer a thorough overview of MNPs in biomedicine and a new sight for their application in tumor treatment.
AB - Iron oxide nanoparticles (MNPs) demonstrate notable benefits in magnetic induction, attributed to their distinctive physical and chemical attributes. Emerging cancer treatment utilizing magnetic fields have also gathered increasing attention in the biomedical field. However, the defects of difficult dispersion and poor biocompatibility of MNPs seriously hinder their application. In order to overcome its inherent defects and maximize the therapeutic potential of MNPs, various functionalized MNPs have been developed, and numerous combined treatment methods based on MNPs have been widely studied. In this review, we compare and analyze the common nanoparticles based on MNPs with different sizes, shapes, and functional modifications. Additionally, we introduced the therapeutic mechanisms of the strategies, such as magnetically controlled targeting, magnetic hyperthermia, and magneto-mechanical effect, which based on the unique magnetic induction capabilities of MNPs. Finally, main challenges of MNPs as smart nanomaterials were also discussed. This review seeks to offer a thorough overview of MNPs in biomedicine and a new sight for their application in tumor treatment.
KW - Magnetic hyperthermia
KW - Magnetic induction
KW - Magnetic nanoparticles
KW - Magnetically controlled targeting
KW - Magneto-mechanical effect
UR - http://www.scopus.com/inward/record.url?scp=85210475651&partnerID=8YFLogxK
U2 - 10.1002/tcr.202400179
DO - 10.1002/tcr.202400179
M3 - 文献综述
C2 - 39607378
AN - SCOPUS:85210475651
SN - 1527-8999
VL - 24
JO - Chemical Record
JF - Chemical Record
IS - 12
M1 - e202400179
ER -
