TY - JOUR
T1 - Cobalt-iron double ion-bovine serum albumin chelation-assisted thermo-sensitive surface-imprinted nanocage with high specificity
AU - Yang, Zuoting
AU - Zhang, Yunfei
AU - Ren, Jianquan
AU - Zhang, Qiuyu
AU - Zhang, Baoliang
N1 - Publisher Copyright:
© XXXX American Chemical Society.
PY - 2021/7/28
Y1 - 2021/7/28
N2 - To develop multifunctional protein imprinted materials, a cobalt-iron double ion-BSA directional chelation-assisted thermo-sensitive surface-imprinted hollow nanocage (Co-Fe@CBMA-MIPs) with excellent specificity is developed on the surface of ZIF-67@Co-Fe in this study by synergizing the advantages of surface imprinting, metal ion chelation, anti-protein adsorption segments, and thermo-sensitive components. Beyond previous research, well-designed multifunctional protein-imprinted materials possess high binding capacity, fast adsorption kinetics, and outstanding selectivity. When the adsorption is carried out at 32 °C, the adsorption capacity of Co-Fe@CBMA-MIPs for BSA reaches 520.35 mg/g within 50 min. The imprinting factor is 8.55. The selectivity factors of Co-Fe@CBMA-MIPs for HSA, Bhb, OVA, and Lyz are 3.72, 6.09, 4.10, and 8.41, respectively. More significantly, Co-Fe@CBMA-MIPs could specifically recognize BSA from mixed proteins and actual samples and exhibit excellent repeated use stability. Based on the above advantages, the development of this research provides an effective means to improve the recognition specificity of molecularly imprinted polymers.
AB - To develop multifunctional protein imprinted materials, a cobalt-iron double ion-BSA directional chelation-assisted thermo-sensitive surface-imprinted hollow nanocage (Co-Fe@CBMA-MIPs) with excellent specificity is developed on the surface of ZIF-67@Co-Fe in this study by synergizing the advantages of surface imprinting, metal ion chelation, anti-protein adsorption segments, and thermo-sensitive components. Beyond previous research, well-designed multifunctional protein-imprinted materials possess high binding capacity, fast adsorption kinetics, and outstanding selectivity. When the adsorption is carried out at 32 °C, the adsorption capacity of Co-Fe@CBMA-MIPs for BSA reaches 520.35 mg/g within 50 min. The imprinting factor is 8.55. The selectivity factors of Co-Fe@CBMA-MIPs for HSA, Bhb, OVA, and Lyz are 3.72, 6.09, 4.10, and 8.41, respectively. More significantly, Co-Fe@CBMA-MIPs could specifically recognize BSA from mixed proteins and actual samples and exhibit excellent repeated use stability. Based on the above advantages, the development of this research provides an effective means to improve the recognition specificity of molecularly imprinted polymers.
KW - Anti-protein segment
KW - MOFs
KW - Protein imprinting
KW - Specific adsorption
KW - Thermo-responsive
UR - http://www.scopus.com/inward/record.url?scp=85111553351&partnerID=8YFLogxK
U2 - 10.1021/acsami.1c06583
DO - 10.1021/acsami.1c06583
M3 - 文章
C2 - 34264633
AN - SCOPUS:85111553351
SN - 1944-8244
VL - 13
SP - 34829
EP - 34842
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 29
ER -