Cobalt-iron double ion-bovine serum albumin chelation-assisted thermo-sensitive surface-imprinted nanocage with high specificity

Zuoting Yang, Yunfei Zhang, Jianquan Ren, Qiuyu Zhang, Baoliang Zhang

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

To develop multifunctional protein imprinted materials, a cobalt-iron double ion-BSA directional chelation-assisted thermo-sensitive surface-imprinted hollow nanocage (Co-Fe@CBMA-MIPs) with excellent specificity is developed on the surface of ZIF-67@Co-Fe in this study by synergizing the advantages of surface imprinting, metal ion chelation, anti-protein adsorption segments, and thermo-sensitive components. Beyond previous research, well-designed multifunctional protein-imprinted materials possess high binding capacity, fast adsorption kinetics, and outstanding selectivity. When the adsorption is carried out at 32 °C, the adsorption capacity of Co-Fe@CBMA-MIPs for BSA reaches 520.35 mg/g within 50 min. The imprinting factor is 8.55. The selectivity factors of Co-Fe@CBMA-MIPs for HSA, Bhb, OVA, and Lyz are 3.72, 6.09, 4.10, and 8.41, respectively. More significantly, Co-Fe@CBMA-MIPs could specifically recognize BSA from mixed proteins and actual samples and exhibit excellent repeated use stability. Based on the above advantages, the development of this research provides an effective means to improve the recognition specificity of molecularly imprinted polymers.

Original languageEnglish
Pages (from-to)34829-34842
Number of pages14
JournalACS Applied Materials and Interfaces
Volume13
Issue number29
DOIs
StatePublished - 28 Jul 2021

Keywords

  • Anti-protein segment
  • MOFs
  • Protein imprinting
  • Specific adsorption
  • Thermo-responsive

Fingerprint

Dive into the research topics of 'Cobalt-iron double ion-bovine serum albumin chelation-assisted thermo-sensitive surface-imprinted nanocage with high specificity'. Together they form a unique fingerprint.

Cite this