Cell type-selective imaging and profiling of newly synthesized proteomes by using puromycin analogues

Shubo Du; Danyang Wang; Jun Seok Lee; Bo Peng; Jingyan Ge; Shao Q. Yao

doi:10.1039/c7cc04536k

Cell type-selective imaging and profiling of newly synthesized proteomes by using puromycin analogues

Shubo Du, Danyang Wang, Jun Seok Lee, Bo Peng, Jingyan Ge, Shao Q. Yao

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We have developed a versatile antibody-assisted strategy for the imaging and profiling of newly synthesized proteomes in a cell-specific manner. This strategy remained highly selective even in heterogeneous co-cultured cells, thus enabling labeling and enrichment of nascent proteomes from targeted cells without the need for physical separation.

Original language	English
Pages (from-to)	8443-8446
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	60
DOIs	https://doi.org/10.1039/c7cc04536k
State	Published - 2017
Externally published	Yes

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title = "Cell type-selective imaging and profiling of newly synthesized proteomes by using puromycin analogues",

abstract = "We have developed a versatile antibody-assisted strategy for the imaging and profiling of newly synthesized proteomes in a cell-specific manner. This strategy remained highly selective even in heterogeneous co-cultured cells, thus enabling labeling and enrichment of nascent proteomes from targeted cells without the need for physical separation.",

author = "Shubo Du and Danyang Wang and Lee, {Jun Seok} and Bo Peng and Jingyan Ge and Yao, {Shao Q.}",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

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volume = "53",

pages = "8443--8446",

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AU - Du, Shubo

AU - Wang, Danyang

AU - Lee, Jun Seok

AU - Peng, Bo

AU - Ge, Jingyan

AU - Yao, Shao Q.

PY - 2017

Y1 - 2017

N2 - We have developed a versatile antibody-assisted strategy for the imaging and profiling of newly synthesized proteomes in a cell-specific manner. This strategy remained highly selective even in heterogeneous co-cultured cells, thus enabling labeling and enrichment of nascent proteomes from targeted cells without the need for physical separation.

AB - We have developed a versatile antibody-assisted strategy for the imaging and profiling of newly synthesized proteomes in a cell-specific manner. This strategy remained highly selective even in heterogeneous co-cultured cells, thus enabling labeling and enrichment of nascent proteomes from targeted cells without the need for physical separation.

UR - http://www.scopus.com/inward/record.url?scp=85026447986&partnerID=8YFLogxK

U2 - 10.1039/c7cc04536k

DO - 10.1039/c7cc04536k

M3 - 文章

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AN - SCOPUS:85026447986

SN - 1359-7345

VL - 53

SP - 8443

EP - 8446

JO - Chemical Communications

JF - Chemical Communications

IS - 60

ER -

Cell type-selective imaging and profiling of newly synthesized proteomes by using puromycin analogues

Abstract

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