Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells

Xiaoming Li; Nan Chen; Yuanyuan Su; Yao He; Min Yin; Min Wei; Lianhui Wang; Wei Huang; Chunhai Fan; Qing Huang

doi:10.1002/adhm.201300294

Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells

Xiaoming Li, Nan Chen, Yuanyuan Su, Yao He, Min Yin, Min Wei, Lianhui Wang, Wei Huang, Chunhai Fan, Qing Huang

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Both CdTe and CdTe/CdS/ZnS quantum dots induce similar levels of autophagy in PC12 and HEK293 cells, while the former exhibits higher toxicity. Low levels of cadmium ions are not sufficient to induce either autophagy or cytotoxicity by themselves. Interestingly, the combination of cadmium ions and CdTe/CdS/ZnS mimics the toxic effect of CdTe, suggesting that autophagy sensitizes cells to cadmium ions.

Original language	English
Pages (from-to)	354-359
Number of pages	6
Journal	Advanced Healthcare Materials
Volume	3
Issue number	3
DOIs	https://doi.org/10.1002/adhm.201300294
State	Published - Mar 2014
Externally published	Yes

Keywords

Autophagy
Cadmium-based quantum dots
Cytotoxicity
Nanoscale effect

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10.1002/adhm.201300294

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title = "Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells",

abstract = "Both CdTe and CdTe/CdS/ZnS quantum dots induce similar levels of autophagy in PC12 and HEK293 cells, while the former exhibits higher toxicity. Low levels of cadmium ions are not sufficient to induce either autophagy or cytotoxicity by themselves. Interestingly, the combination of cadmium ions and CdTe/CdS/ZnS mimics the toxic effect of CdTe, suggesting that autophagy sensitizes cells to cadmium ions.",

keywords = "Autophagy, Cadmium-based quantum dots, Cytotoxicity, Nanoscale effect",

author = "Xiaoming Li and Nan Chen and Yuanyuan Su and Yao He and Min Yin and Min Wei and Lianhui Wang and Wei Huang and Chunhai Fan and Qing Huang",

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AU - Li, Xiaoming

AU - Chen, Nan

AU - Su, Yuanyuan

AU - He, Yao

AU - Yin, Min

AU - Wei, Min

AU - Wang, Lianhui

AU - Huang, Wei

AU - Fan, Chunhai

AU - Huang, Qing

PY - 2014/3

Y1 - 2014/3

N2 - Both CdTe and CdTe/CdS/ZnS quantum dots induce similar levels of autophagy in PC12 and HEK293 cells, while the former exhibits higher toxicity. Low levels of cadmium ions are not sufficient to induce either autophagy or cytotoxicity by themselves. Interestingly, the combination of cadmium ions and CdTe/CdS/ZnS mimics the toxic effect of CdTe, suggesting that autophagy sensitizes cells to cadmium ions.

AB - Both CdTe and CdTe/CdS/ZnS quantum dots induce similar levels of autophagy in PC12 and HEK293 cells, while the former exhibits higher toxicity. Low levels of cadmium ions are not sufficient to induce either autophagy or cytotoxicity by themselves. Interestingly, the combination of cadmium ions and CdTe/CdS/ZnS mimics the toxic effect of CdTe, suggesting that autophagy sensitizes cells to cadmium ions.

KW - Autophagy

KW - Cadmium-based quantum dots

KW - Cytotoxicity

KW - Nanoscale effect

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M3 - 文章

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JO - Advanced Healthcare Materials

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ER -

Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells

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Keywords

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