TY - JOUR
T1 - Asymmetric Synthesis of Enantioenriched 6-Hydroxyl Butyrolactams Promoted by N-Heterocyclic Carbene
AU - Hu, Zhouli
AU - Zhu, Ying
AU - Fu, Zhenqian
AU - Huang, Wei
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/8/16
Y1 - 2019/8/16
N2 - Herein, an efficient route to synthesize 6-hydroxyl butyrolactams has been successfully developed via an N-heterocyclic carbene-catalyzed formal [3 + 2] annulation of bromoenals with α-amino ketones, followed by reduction. Remarkably, enantioenriched epi-neoclausenamide, which is one of the clausenamide derivatives, could be efficiently prepared by this strategy.
AB - Herein, an efficient route to synthesize 6-hydroxyl butyrolactams has been successfully developed via an N-heterocyclic carbene-catalyzed formal [3 + 2] annulation of bromoenals with α-amino ketones, followed by reduction. Remarkably, enantioenriched epi-neoclausenamide, which is one of the clausenamide derivatives, could be efficiently prepared by this strategy.
UR - http://www.scopus.com/inward/record.url?scp=85071351690&partnerID=8YFLogxK
U2 - 10.1021/acs.joc.9b01490
DO - 10.1021/acs.joc.9b01490
M3 - 文章
C2 - 31328524
AN - SCOPUS:85071351690
SN - 0022-3263
VL - 84
SP - 10328
EP - 10337
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 16
ER -