Anti-nonspecific adsorption segments-assisted self-driven surface imprinted fibers for efficient protein separation

Zuoting Yang, Ting Wang, Yabin Wang, Qiuyu Zhang, Baoliang Zhang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

At present, the development of high-performance protein imprinted materials is still a research hotspot in the field of protein imprinting. Herein, anti-protein adsorption segment (CBMA)-assisted self-driven bovine serum albumin (BSA) surface imprinted fibers MTCFs@SIP@CBMA with high recognition selectivity are pioneered using the strategies of combining magnetic nanomaterial surface imprinting technique with amino-Michael addition. The special structure of the carrier MTCFs endows MTCFs@SIP@CBMA with magnetic performance and self-driven adsorption performance, which simplifies the separation process while improving the adsorption capacity and accelerating the adsorption rate. The adsorption capacity for BSA reached 390 ± 20 mg/g within 30 min. The introduction of CBMA segments on the surface after imprinting by amino-Michael addition makes its polymer chain length and position controllable. Under the strongest anti-nonspecific adsorption effect, MTCFs@SIP@CBMA exhibit excellent specific identification to BSA from mixed proteins. Additionally, MTCFs@SIP@CBMA show considerable reusability. Therefore, MTCFs@SIP@CBMA are expected to be applied in efficient separation of proteins in biological samples.

Original languageEnglish
JournalAIChE Journal
DOIs
StateAccepted/In press - 2022

Keywords

  • anti-protein adsorption
  • high recognition selectivity
  • magnetic tubular nanofiber
  • protein imprinted materials
  • self-driven adsorption

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