@inproceedings{94d84dac5b574802a354439ae42ab9a7,
title = "Analysis of Disease Comorbidity Patterns in a Large-Scale China Population",
abstract = "Background: Disease comorbidity is popular and has significant indications for disease progress and management. We aim to detect the general disease comorbidity patterns in Chinese populations using a large-scale clinical data set. Materials and Methods: We extracted the diseases from a large-scale anonymized data set derived from 8,572,137 inpatients in 453 hospitals across China. We built a Disease Comorbidity Network (DCN) with significant disease co-occurrence and detected the topological patterns of disease comorbidity using both complex network and data mining methods. Results: We obtained the DCN with 5702 nodes and 258,535 edges, which shows a power law distribution of the degree and weight. It indicated that there exists high heterogeneity of comorbidities for different diseases. Meanwhile, we found that the DCN is a hierarchical modular network with community structures. We further divided the network into 10 modules using community detection algorithm, which showed two types of modules exist in the DCN. Conclusions: Our study indicates that disease comorbidity is significant and valuable to understand the disease incidences and their interactions in real-world populations, which will provide important insights for detection of the patterns of disease classification, diagnosis and prognosis.",
keywords = "Complex network, Disease comorbidity, Network medicine",
author = "Mengfei Guo and Yanan Yu and Tiancai Wen and Xiaoping Zhang and Baoyan Liu and Jin Zhang and Runshun Zhang and Yanning Zhang and Xuezhong Zhou",
note = "Publisher Copyright: {\textcopyright} Springer International Publishing AG, part of Springer Nature 2018.; 14th International Conference on Intelligent Computing, ICIC 2018 ; Conference date: 15-08-2018 Through 18-08-2018",
year = "2018",
doi = "10.1007/978-3-319-95933-7_34",
language = "英语",
isbn = "9783319959320",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "272--278",
editor = "Kang-Hyun Jo and De-Shuang Huang and Xiao-Long Zhang",
booktitle = "Intelligent Computing Theories and Application - 14th International Conference, ICIC 2018, Proceedings",
}