Analysis of Disease Comorbidity Patterns in a Large-Scale China Population

Mengfei Guo, Yanan Yu, Tiancai Wen, Xiaoping Zhang, Baoyan Liu, Jin Zhang, Runshun Zhang, Yanning Zhang, Xuezhong Zhou

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Background: Disease comorbidity is popular and has significant indications for disease progress and management. We aim to detect the general disease comorbidity patterns in Chinese populations using a large-scale clinical data set. Materials and Methods: We extracted the diseases from a large-scale anonymized data set derived from 8,572,137 inpatients in 453 hospitals across China. We built a Disease Comorbidity Network (DCN) with significant disease co-occurrence and detected the topological patterns of disease comorbidity using both complex network and data mining methods. Results: We obtained the DCN with 5702 nodes and 258,535 edges, which shows a power law distribution of the degree and weight. It indicated that there exists high heterogeneity of comorbidities for different diseases. Meanwhile, we found that the DCN is a hierarchical modular network with community structures. We further divided the network into 10 modules using community detection algorithm, which showed two types of modules exist in the DCN. Conclusions: Our study indicates that disease comorbidity is significant and valuable to understand the disease incidences and their interactions in real-world populations, which will provide important insights for detection of the patterns of disease classification, diagnosis and prognosis.

Original languageEnglish
Title of host publicationIntelligent Computing Theories and Application - 14th International Conference, ICIC 2018, Proceedings
EditorsKang-Hyun Jo, De-Shuang Huang, Xiao-Long Zhang
PublisherSpringer Verlag
Pages272-278
Number of pages7
ISBN (Print)9783319959320
DOIs
StatePublished - 2018
Event14th International Conference on Intelligent Computing, ICIC 2018 - Wuhan, China
Duration: 15 Aug 201818 Aug 2018

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume10955 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference14th International Conference on Intelligent Computing, ICIC 2018
Country/TerritoryChina
CityWuhan
Period15/08/1818/08/18

Keywords

  • Complex network
  • Disease comorbidity
  • Network medicine

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