TY - GEN
T1 - An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels
AU - Li, Ding
AU - Li, Xiaoping
AU - Chang, Honglong
N1 - Publisher Copyright:
© 2018 IEEE.
PY - 2018/4/24
Y1 - 2018/4/24
N2 - This paper reports an integrated ion chromatography microchip for the fast, low-cost and reproducible measurement of glycated hemoglobin (HbAlc). Except the pump, all chromatography components including four membrane microvalves, a packed column, two porous frits and an optical detector cell are integrated on the single chip. In the experiments, the HbA1c levels can be precisely measured with fewer samples (1 μl) in a shorter period of time (5 mins) compared to the state-of-the-art nanoflow liquid chromatography (LC) microchip (4 μl & 50 mins). The coefficient of variation (c.v.) for three consecutive measurements of HbA1c calibrators was from 3.1% to 9.0%, indicating that the measurement was reproducible and the chip can be used for point-of-care diabetes diagnosis.
AB - This paper reports an integrated ion chromatography microchip for the fast, low-cost and reproducible measurement of glycated hemoglobin (HbAlc). Except the pump, all chromatography components including four membrane microvalves, a packed column, two porous frits and an optical detector cell are integrated on the single chip. In the experiments, the HbA1c levels can be precisely measured with fewer samples (1 μl) in a shorter period of time (5 mins) compared to the state-of-the-art nanoflow liquid chromatography (LC) microchip (4 μl & 50 mins). The coefficient of variation (c.v.) for three consecutive measurements of HbA1c calibrators was from 3.1% to 9.0%, indicating that the measurement was reproducible and the chip can be used for point-of-care diabetes diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=85047003951&partnerID=8YFLogxK
U2 - 10.1109/MEMSYS.2018.8346775
DO - 10.1109/MEMSYS.2018.8346775
M3 - 会议稿件
AN - SCOPUS:85047003951
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 1189
EP - 1192
BT - 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018
Y2 - 21 January 2018 through 25 January 2018
ER -
