An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex

Yuanyuan Tian; Lei Zhang; Jingjing Shen; Lingzhi Wu; Hongzhang He; Dik Lung Ma; Chung Hang Leung; Weibing Wu; Quli Fan; Wei Huang; Lianhui Wang

doi:10.1002/smll.201600041

An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex

Yuanyuan Tian, Lei Zhang, Jingjing Shen, Lingzhi Wu, Hongzhang He, Dik Lung Ma, Chung Hang Leung, Weibing Wu, Quli Fan, Wei Huang, Lianhui Wang

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Promoted by the localized surface plasmon resonance nanotechnology, a simple and sensitive plasmonic aptamer nanosensor (nanoaptasensor) on an individual Au@Ag core-shell nanocube (Au@Ag NC) has been proposed for real-time monitoring of the formation process of G-quadruplex structures and label-free analysis of potassium ions (K⁺). In particular, the analysis of the thermodynamic parameters indicates that there are two types of binding states accompanied with a remarkable change of free energy (ΔG) in the sequential folding process of telomere DNA sequence. This nanoaptasensor has raised promising applications in monitoring the dynamic process of the structural switch of the G-quadruplex.

Original language	English
Pages (from-to)	2913-2920
Number of pages	8
Journal	Small
Volume	12
Issue number	21
DOIs	https://doi.org/10.1002/smll.201600041
State	Published - 1 Jun 2016
Externally published	Yes

Keywords

core-shell nanocubes
G-quadruplex
localized surface plasmon resonance
nanoaptasensors, biosensors

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10.1002/smll.201600041

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title = "An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex",

abstract = "Promoted by the localized surface plasmon resonance nanotechnology, a simple and sensitive plasmonic aptamer nanosensor (nanoaptasensor) on an individual Au@Ag core-shell nanocube (Au@Ag NC) has been proposed for real-time monitoring of the formation process of G-quadruplex structures and label-free analysis of potassium ions (K+). In particular, the analysis of the thermodynamic parameters indicates that there are two types of binding states accompanied with a remarkable change of free energy (ΔG) in the sequential folding process of telomere DNA sequence. This nanoaptasensor has raised promising applications in monitoring the dynamic process of the structural switch of the G-quadruplex.",

keywords = "core-shell nanocubes, G-quadruplex, localized surface plasmon resonance, nanoaptasensors, biosensors",

author = "Yuanyuan Tian and Lei Zhang and Jingjing Shen and Lingzhi Wu and Hongzhang He and Ma, {Dik Lung} and Leung, {Chung Hang} and Weibing Wu and Quli Fan and Wei Huang and Lianhui Wang",

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year = "2016",

month = jun,

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doi = "10.1002/smll.201600041",

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T1 - An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex

AU - Tian, Yuanyuan

AU - Zhang, Lei

AU - Shen, Jingjing

AU - Wu, Lingzhi

AU - He, Hongzhang

AU - Ma, Dik Lung

AU - Leung, Chung Hang

AU - Wu, Weibing

AU - Fan, Quli

AU - Huang, Wei

AU - Wang, Lianhui

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Promoted by the localized surface plasmon resonance nanotechnology, a simple and sensitive plasmonic aptamer nanosensor (nanoaptasensor) on an individual Au@Ag core-shell nanocube (Au@Ag NC) has been proposed for real-time monitoring of the formation process of G-quadruplex structures and label-free analysis of potassium ions (K+). In particular, the analysis of the thermodynamic parameters indicates that there are two types of binding states accompanied with a remarkable change of free energy (ΔG) in the sequential folding process of telomere DNA sequence. This nanoaptasensor has raised promising applications in monitoring the dynamic process of the structural switch of the G-quadruplex.

AB - Promoted by the localized surface plasmon resonance nanotechnology, a simple and sensitive plasmonic aptamer nanosensor (nanoaptasensor) on an individual Au@Ag core-shell nanocube (Au@Ag NC) has been proposed for real-time monitoring of the formation process of G-quadruplex structures and label-free analysis of potassium ions (K+). In particular, the analysis of the thermodynamic parameters indicates that there are two types of binding states accompanied with a remarkable change of free energy (ΔG) in the sequential folding process of telomere DNA sequence. This nanoaptasensor has raised promising applications in monitoring the dynamic process of the structural switch of the G-quadruplex.

KW - core-shell nanocubes

KW - G-quadruplex

KW - localized surface plasmon resonance

KW - nanoaptasensors, biosensors

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An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex

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Keywords

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