Ag(i)-Mediated hydrogen isotope exchange of mono-fluorinated (hetero)arenes

Guang Qi Hu; En Ci Li; Hong Hai Zhang; Wei Huang

doi:10.1039/d0ob01273d

Ag(i)-Mediated hydrogen isotope exchange of mono-fluorinated (hetero)arenes

Guang Qi Hu, En Ci Li, Hong Hai Zhang, Wei Huang

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

An efficient approach to install deuterium into mono-fluorinated (hetero)arenes by a Ag2CO3/Sphos-mediated HIE protocol with D2O as the deuterium source has been disclosed. This method showed a specific site selectivity of deuteration at the α-position of the fluorine atom, which is complementary to the existing transition metal-catalyzed HIE process.

Original language	English
Pages (from-to)	6627-6633
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	18
Issue number	34
DOIs	https://doi.org/10.1039/d0ob01273d
State	Published - 14 Sep 2020
Externally published	Yes

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abstract = "An efficient approach to install deuterium into mono-fluorinated (hetero)arenes by a Ag2CO3/Sphos-mediated HIE protocol with D2O as the deuterium source has been disclosed. This method showed a specific site selectivity of deuteration at the α-position of the fluorine atom, which is complementary to the existing transition metal-catalyzed HIE process.",

author = "Hu, {Guang Qi} and Li, {En Ci} and Zhang, {Hong Hai} and Wei Huang",

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AU - Li, En Ci

AU - Zhang, Hong Hai

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PY - 2020/9/14

Y1 - 2020/9/14

N2 - An efficient approach to install deuterium into mono-fluorinated (hetero)arenes by a Ag2CO3/Sphos-mediated HIE protocol with D2O as the deuterium source has been disclosed. This method showed a specific site selectivity of deuteration at the α-position of the fluorine atom, which is complementary to the existing transition metal-catalyzed HIE process.

AB - An efficient approach to install deuterium into mono-fluorinated (hetero)arenes by a Ag2CO3/Sphos-mediated HIE protocol with D2O as the deuterium source has been disclosed. This method showed a specific site selectivity of deuteration at the α-position of the fluorine atom, which is complementary to the existing transition metal-catalyzed HIE process.

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DO - 10.1039/d0ob01273d

M3 - 文章

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AN - SCOPUS:85090252285

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EP - 6633

JO - Organic and Biomolecular Chemistry

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ER -

Ag(i)-Mediated hydrogen isotope exchange of mono-fluorinated (hetero)arenes

Abstract

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