Advances in magnetic resonance imaging of the developing brain and its applications in pediatrics

Rui Ke Chen; Ming Yang Li; Zhi Yong Zhao; Hao An Xu; Cheng Lin Ning; Jie Lu; Qin Feng Zhu; Yong Quan Huang; Ruo Ke Zhao; Ling Xuan Zhang; Tian Li Tao; Kai Bo Tang; Jia Le Cheng; Can Lai; Hong Xi Zhang; Xiao Hui Ma; Hosung Kim; Zhi Hua Ren; Chun Feng Lian; Fan Wang; Geng Chen; Min Hui Ouyang; An Qi Qiu; Han Zhang; Xiao Qi Huang; Xu Jun Duan; Gang Li; Jian Yang; Hao Huang; Kenichi Oishi; Ellen Grant; Wei Li Lin; Duan Xu; Dan Wu

doi:10.1007/s12519-025-00905-7

Advances in magnetic resonance imaging of the developing brain and its applications in pediatrics

Rui Ke Chen, Ming Yang Li, Zhi Yong Zhao, Hao An Xu, Cheng Lin Ning, Jie Lu, Qin Feng Zhu, Yong Quan Huang, Ruo Ke Zhao, Ling Xuan Zhang, Tian Li Tao, Kai Bo Tang, Jia Le Cheng, Can Lai, Hong Xi Zhang, Xiao Hui Ma, Hosung Kim, Zhi Hua Ren, Chun Feng Lian, Fan WangGeng Chen, Min Hui Ouyang, An Qi Qiu, Han Zhang, Xiao Qi Huang, Xu Jun Duan, Gang Li, Jian Yang, Hao Huang, Kenichi Oishi, Ellen Grant, Wei Li Lin, Duan Xu, Dan Wu

School of Computer Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Abstract: The human brain undergoes a complex and dynamic developmental process from birth through adolescence, driven by molecular and cellular mechanisms that shape its structure and function. Magnetic resonance imaging (MRI) has become an essential non-invasive tool for studying pediatric brain development and detecting neurological disorders. However, pediatric neuroimaging presents unique challenges, including motion artifacts, small anatomical structures, and immature tissue properties, necessitating specialized MRI techniques. This review provides an overview of recent advancements in MRI hardware, acquisition strategies, and analytical methods optimized for pediatric brain imaging. Furthermore, it summarizes the applications of these techniques in understanding normal brain development, neurodevelopmental disorders, and the impact of early-life risk factors. This review highlights the progresses in pediatric MRI, emphasizing its critical role in advancing our understanding of pediatric brain development and neurological health. It also outlines the challenges and future directions in pediatric MRI to further improve imaging precision and clinical utility. Graphic Abstract: (Figure presented.)

Original language	English
Article number	e3944
Journal	World Journal of Pediatrics
DOIs	https://doi.org/10.1007/s12519-025-00905-7
State	Accepted/In press - 2025

Keywords

Brain development
Magnetic resonance imaging
Neuroimaging
Neurological disorders
Pediatrics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12519-025-00905-7

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Chen, R. K., Li, M. Y., Zhao, Z. Y., Xu, H. A., Ning, C. L., Lu, J., Zhu, Q. F., Huang, Y. Q., Zhao, R. K., Zhang, L. X., Tao, T. L., Tang, K. B., Cheng, J. L., Lai, C., Zhang, H. X., Ma, X. H., Kim, H., Ren, Z. H., Lian, C. F., ... Wu, D. (Accepted/In press). Advances in magnetic resonance imaging of the developing brain and its applications in pediatrics. World Journal of Pediatrics, Article e3944. https://doi.org/10.1007/s12519-025-00905-7

@article{7a932f79b4ad4b338469830d635ef47a,

title = "Advances in magnetic resonance imaging of the developing brain and its applications in pediatrics",

abstract = "Abstract: The human brain undergoes a complex and dynamic developmental process from birth through adolescence, driven by molecular and cellular mechanisms that shape its structure and function. Magnetic resonance imaging (MRI) has become an essential non-invasive tool for studying pediatric brain development and detecting neurological disorders. However, pediatric neuroimaging presents unique challenges, including motion artifacts, small anatomical structures, and immature tissue properties, necessitating specialized MRI techniques. This review provides an overview of recent advancements in MRI hardware, acquisition strategies, and analytical methods optimized for pediatric brain imaging. Furthermore, it summarizes the applications of these techniques in understanding normal brain development, neurodevelopmental disorders, and the impact of early-life risk factors. This review highlights the progresses in pediatric MRI, emphasizing its critical role in advancing our understanding of pediatric brain development and neurological health. It also outlines the challenges and future directions in pediatric MRI to further improve imaging precision and clinical utility. Graphic Abstract: (Figure presented.)",

keywords = "Brain development, Magnetic resonance imaging, Neuroimaging, Neurological disorders, Pediatrics",

author = "Chen, {Rui Ke} and Li, {Ming Yang} and Zhao, {Zhi Yong} and Xu, {Hao An} and Ning, {Cheng Lin} and Jie Lu and Zhu, {Qin Feng} and Huang, {Yong Quan} and Zhao, {Ruo Ke} and Zhang, {Ling Xuan} and Tao, {Tian Li} and Tang, {Kai Bo} and Cheng, {Jia Le} and Can Lai and Zhang, {Hong Xi} and Ma, {Xiao Hui} and Hosung Kim and Ren, {Zhi Hua} and Lian, {Chun Feng} and Fan Wang and Geng Chen and Ouyang, {Min Hui} and Qiu, {An Qi} and Han Zhang and Huang, {Xiao Qi} and Duan, {Xu Jun} and Gang Li and Jian Yang and Hao Huang and Kenichi Oishi and Ellen Grant and Lin, {Wei Li} and Duan Xu and Dan Wu",

note = "Publisher Copyright: {\textcopyright} Children's Hospital, Zhejiang University School of Medicine 2025.",

year = "2025",

doi = "10.1007/s12519-025-00905-7",

language = "英语",

journal = "World Journal of Pediatrics",

issn = "1867-0687",

}

Chen, RK, Li, MY, Zhao, ZY, Xu, HA, Ning, CL, Lu, J, Zhu, QF, Huang, YQ, Zhao, RK, Zhang, LX, Tao, TL, Tang, KB, Cheng, JL, Lai, C, Zhang, HX, Ma, XH, Kim, H, Ren, ZH, Lian, CF, Wang, F, Chen, G, Ouyang, MH, Qiu, AQ, Zhang, H, Huang, XQ, Duan, XJ, Li, G, Yang, J, Huang, H, Oishi, K, Grant, E, Lin, WL, Xu, D & Wu, D 2025, 'Advances in magnetic resonance imaging of the developing brain and its applications in pediatrics', World Journal of Pediatrics. https://doi.org/10.1007/s12519-025-00905-7

TY - JOUR

T1 - Advances in magnetic resonance imaging of the developing brain and its applications in pediatrics

AU - Chen, Rui Ke

AU - Li, Ming Yang

AU - Zhao, Zhi Yong

AU - Xu, Hao An

AU - Ning, Cheng Lin

AU - Lu, Jie

AU - Zhu, Qin Feng

AU - Huang, Yong Quan

AU - Zhao, Ruo Ke

AU - Zhang, Ling Xuan

AU - Tao, Tian Li

AU - Tang, Kai Bo

AU - Cheng, Jia Le

AU - Lai, Can

AU - Zhang, Hong Xi

AU - Ma, Xiao Hui

AU - Kim, Hosung

AU - Ren, Zhi Hua

AU - Lian, Chun Feng

AU - Wang, Fan

AU - Chen, Geng

AU - Ouyang, Min Hui

AU - Qiu, An Qi

AU - Zhang, Han

AU - Huang, Xiao Qi

AU - Duan, Xu Jun

AU - Li, Gang

AU - Yang, Jian

AU - Huang, Hao

AU - Oishi, Kenichi

AU - Grant, Ellen

AU - Lin, Wei Li

AU - Xu, Duan

AU - Wu, Dan

PY - 2025

Y1 - 2025

N2 - Abstract: The human brain undergoes a complex and dynamic developmental process from birth through adolescence, driven by molecular and cellular mechanisms that shape its structure and function. Magnetic resonance imaging (MRI) has become an essential non-invasive tool for studying pediatric brain development and detecting neurological disorders. However, pediatric neuroimaging presents unique challenges, including motion artifacts, small anatomical structures, and immature tissue properties, necessitating specialized MRI techniques. This review provides an overview of recent advancements in MRI hardware, acquisition strategies, and analytical methods optimized for pediatric brain imaging. Furthermore, it summarizes the applications of these techniques in understanding normal brain development, neurodevelopmental disorders, and the impact of early-life risk factors. This review highlights the progresses in pediatric MRI, emphasizing its critical role in advancing our understanding of pediatric brain development and neurological health. It also outlines the challenges and future directions in pediatric MRI to further improve imaging precision and clinical utility. Graphic Abstract: (Figure presented.)

AB - Abstract: The human brain undergoes a complex and dynamic developmental process from birth through adolescence, driven by molecular and cellular mechanisms that shape its structure and function. Magnetic resonance imaging (MRI) has become an essential non-invasive tool for studying pediatric brain development and detecting neurological disorders. However, pediatric neuroimaging presents unique challenges, including motion artifacts, small anatomical structures, and immature tissue properties, necessitating specialized MRI techniques. This review provides an overview of recent advancements in MRI hardware, acquisition strategies, and analytical methods optimized for pediatric brain imaging. Furthermore, it summarizes the applications of these techniques in understanding normal brain development, neurodevelopmental disorders, and the impact of early-life risk factors. This review highlights the progresses in pediatric MRI, emphasizing its critical role in advancing our understanding of pediatric brain development and neurological health. It also outlines the challenges and future directions in pediatric MRI to further improve imaging precision and clinical utility. Graphic Abstract: (Figure presented.)

KW - Brain development

KW - Magnetic resonance imaging

KW - Neuroimaging

KW - Neurological disorders

KW - Pediatrics

UR - http://www.scopus.com/inward/record.url?scp=105006821145&partnerID=8YFLogxK

U2 - 10.1007/s12519-025-00905-7

DO - 10.1007/s12519-025-00905-7

M3 - 文献综述

AN - SCOPUS:105006821145

SN - 1867-0687

JO - World Journal of Pediatrics

JF - World Journal of Pediatrics

M1 - e3944

ER -

Advances in magnetic resonance imaging of the developing brain and its applications in pediatrics

Abstract

Keywords

UN SDGs

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