Access to Highly Functionalized Indanes from Arynes and α,γ-Diketo Esters

Wanyao Hu; Cong Zhang; Jie Huang; Yingying Guo; Zhenqian Fu; Wei Huang

doi:10.1021/acs.orglett.8b03919

Access to Highly Functionalized Indanes from Arynes and α,γ-Diketo Esters

Wanyao Hu, Cong Zhang, Jie Huang, Yingying Guo, Zhenqian Fu, Wei Huang

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

An unprecedented method for the synthesis of highly functionalized indanes from arynes and α,γ-diketo esters is described. Importantly, mild and nearly pH-neutral conditions ensure excellent functional group tolerance. Theoretical studies indicated that the reaction proceeds through a benzocyclobutane intermediate.

Original language	English
Pages (from-to)	941-945
Number of pages	5
Journal	Organic Letters
Volume	21
Issue number	4
DOIs	https://doi.org/10.1021/acs.orglett.8b03919
State	Published - 15 Feb 2019
Externally published	Yes

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10.1021/acs.orglett.8b03919

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title = "Access to Highly Functionalized Indanes from Arynes and α,γ-Diketo Esters",

abstract = "An unprecedented method for the synthesis of highly functionalized indanes from arynes and α,γ-diketo esters is described. Importantly, mild and nearly pH-neutral conditions ensure excellent functional group tolerance. Theoretical studies indicated that the reaction proceeds through a benzocyclobutane intermediate.",

author = "Wanyao Hu and Cong Zhang and Jie Huang and Yingying Guo and Zhenqian Fu and Wei Huang",

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T1 - Access to Highly Functionalized Indanes from Arynes and α,γ-Diketo Esters

AU - Hu, Wanyao

AU - Zhang, Cong

AU - Huang, Jie

AU - Guo, Yingying

AU - Fu, Zhenqian

AU - Huang, Wei

PY - 2019/2/15

Y1 - 2019/2/15

N2 - An unprecedented method for the synthesis of highly functionalized indanes from arynes and α,γ-diketo esters is described. Importantly, mild and nearly pH-neutral conditions ensure excellent functional group tolerance. Theoretical studies indicated that the reaction proceeds through a benzocyclobutane intermediate.

AB - An unprecedented method for the synthesis of highly functionalized indanes from arynes and α,γ-diketo esters is described. Importantly, mild and nearly pH-neutral conditions ensure excellent functional group tolerance. Theoretical studies indicated that the reaction proceeds through a benzocyclobutane intermediate.

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U2 - 10.1021/acs.orglett.8b03919

DO - 10.1021/acs.orglett.8b03919

M3 - 文章

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SN - 1523-7060

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SP - 941

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JF - Organic Letters

IS - 4

ER -

Access to Highly Functionalized Indanes from Arynes and α,γ-Diketo Esters

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