Abstract
Herein, an efficient route to amides from aldimines via aza-Breslow intermediates through aerobic oxidative carbene catalysis with LiCl as a cooperative Lewis acid is described. Many of the obtained N-heteroarylamides feature biological activity. Ambient air was used as the sole oxidant and source of oxygen in this catalytically oxidative amidation. This method allows for a broad substrate scope and mild conditions. The aza-Breslow intermediate derivative was isolated and its crystal structure confirmed.
Original language | English |
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Pages (from-to) | 3362-3365 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 19 |
Issue number | 13 |
DOIs | |
State | Published - 7 Jul 2017 |
Externally published | Yes |