TY - JOUR
T1 - A review of magnet systems for targeted drug delivery
AU - Liu, Ya Li
AU - Chen, Da
AU - Shang, Peng
AU - Yin, Da Chuan
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/5/28
Y1 - 2019/5/28
N2 - Magnetic drug targeting is a method by which magnetic drug carriers in the body are manipulated by external magnetic fields to reach the target area. This method is potentially promising in applications for treatment of diseases like cancers, nervous system diseases, sudden sensorineural hearing loss, and so on, due to the advantages in that it can improve efficacy, reduce drug dosage and side effects. Therefore, it has received extensive attention in recent years. Successful magnetic drug targeting requires a good magnet system to guide the drug carriers to the target site. Up to date there have been many efforts to design the magnet systems for targeted drug delivery. However, there are few comprehensive reviews on these systems. Here we review the progresses made in this field. We summarized the systems already developed or proposed, and categorized them into two groups: static field magnet systems and varying field magnet systems. Based on the requirements for more powerful targeting performance, the prospects and the future research directions in this field are anticipated.
AB - Magnetic drug targeting is a method by which magnetic drug carriers in the body are manipulated by external magnetic fields to reach the target area. This method is potentially promising in applications for treatment of diseases like cancers, nervous system diseases, sudden sensorineural hearing loss, and so on, due to the advantages in that it can improve efficacy, reduce drug dosage and side effects. Therefore, it has received extensive attention in recent years. Successful magnetic drug targeting requires a good magnet system to guide the drug carriers to the target site. Up to date there have been many efforts to design the magnet systems for targeted drug delivery. However, there are few comprehensive reviews on these systems. Here we review the progresses made in this field. We summarized the systems already developed or proposed, and categorized them into two groups: static field magnet systems and varying field magnet systems. Based on the requirements for more powerful targeting performance, the prospects and the future research directions in this field are anticipated.
KW - Drug delivery
KW - Drug delivery system (DDS)
KW - Magnet systems
KW - Magnetic drug carrier
KW - Magnetic drug targeting
KW - Magnetic nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85063897511&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2019.03.031
DO - 10.1016/j.jconrel.2019.03.031
M3 - 文献综述
C2 - 30946854
AN - SCOPUS:85063897511
SN - 0168-3659
VL - 302
SP - 90
EP - 104
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -
