A novel pyrimidine based deep-red fluorogenic probe for detecting hydrogen peroxide in Parkinson's disease models

Xinghan Qiu; Chenqi Xin; Wenjing Qin; Zheng Li; Duoteng Zhang; Gaobin Zhang; Bo Peng; Xu Han; Changmin Yu; Lin Li; Wei Huang

doi:10.1016/j.talanta.2019.03.017

A novel pyrimidine based deep-red fluorogenic probe for detecting hydrogen peroxide in Parkinson's disease models

Xinghan Qiu, Chenqi Xin, Wenjing Qin, Zheng Li, Duoteng Zhang, Gaobin Zhang, Bo Peng, Xu Han, Changmin Yu, Lin Li, Wei Huang

Institute of Flexible Electronics

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Parkinson's disease (PD) severely affects life quality of patients and has brought huge economic burden to health system worldwide. Previous studies have shown that the abnormal expression of hydrogen peroxide (H₂O₂) in the brain is closely related to the development of neurodegenerative diseases such as PD. Herein, we designed a novel deep-red H₂O₂ fluorogenic probe PB1 to detect the level of H₂O₂ in vivo. PB1 showed a highly selectivity response to H₂O₂ over other reactants such as reactive oxygen/nitrogen species, biothiols and various ions in aqueous solution at physiological pH. We have demonstrated that PB1 possesses an excellent response to H₂O₂ in the cells and in the brain tissue of drosophila from confocal fluorescence imaging. These results suggested that PB1 holds great potential in the study of the relationship between H₂O₂ overexpression and PD.

Original language	English
Pages (from-to)	628-633
Number of pages	6
Journal	Talanta
Volume	199
DOIs	https://doi.org/10.1016/j.talanta.2019.03.017
State	Published - 1 Jul 2019

Keywords

Cell and tissue imaging
Deep-red
Hydrogen peroxide
Parkinson's disease

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title = "A novel pyrimidine based deep-red fluorogenic probe for detecting hydrogen peroxide in Parkinson's disease models",

abstract = "Parkinson's disease (PD) severely affects life quality of patients and has brought huge economic burden to health system worldwide. Previous studies have shown that the abnormal expression of hydrogen peroxide (H2O2) in the brain is closely related to the development of neurodegenerative diseases such as PD. Herein, we designed a novel deep-red H2O2 fluorogenic probe PB1 to detect the level of H2O2 in vivo. PB1 showed a highly selectivity response to H2O2 over other reactants such as reactive oxygen/nitrogen species, biothiols and various ions in aqueous solution at physiological pH. We have demonstrated that PB1 possesses an excellent response to H2O2 in the cells and in the brain tissue of drosophila from confocal fluorescence imaging. These results suggested that PB1 holds great potential in the study of the relationship between H2O2 overexpression and PD.",

keywords = "Cell and tissue imaging, Deep-red, Hydrogen peroxide, Parkinson's disease",

author = "Xinghan Qiu and Chenqi Xin and Wenjing Qin and Zheng Li and Duoteng Zhang and Gaobin Zhang and Bo Peng and Xu Han and Changmin Yu and Lin Li and Wei Huang",

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doi = "10.1016/j.talanta.2019.03.017",

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T1 - A novel pyrimidine based deep-red fluorogenic probe for detecting hydrogen peroxide in Parkinson's disease models

AU - Qiu, Xinghan

AU - Xin, Chenqi

AU - Qin, Wenjing

AU - Li, Zheng

AU - Zhang, Duoteng

AU - Zhang, Gaobin

AU - Peng, Bo

AU - Han, Xu

AU - Yu, Changmin

AU - Li, Lin

AU - Huang, Wei

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Parkinson's disease (PD) severely affects life quality of patients and has brought huge economic burden to health system worldwide. Previous studies have shown that the abnormal expression of hydrogen peroxide (H2O2) in the brain is closely related to the development of neurodegenerative diseases such as PD. Herein, we designed a novel deep-red H2O2 fluorogenic probe PB1 to detect the level of H2O2 in vivo. PB1 showed a highly selectivity response to H2O2 over other reactants such as reactive oxygen/nitrogen species, biothiols and various ions in aqueous solution at physiological pH. We have demonstrated that PB1 possesses an excellent response to H2O2 in the cells and in the brain tissue of drosophila from confocal fluorescence imaging. These results suggested that PB1 holds great potential in the study of the relationship between H2O2 overexpression and PD.

AB - Parkinson's disease (PD) severely affects life quality of patients and has brought huge economic burden to health system worldwide. Previous studies have shown that the abnormal expression of hydrogen peroxide (H2O2) in the brain is closely related to the development of neurodegenerative diseases such as PD. Herein, we designed a novel deep-red H2O2 fluorogenic probe PB1 to detect the level of H2O2 in vivo. PB1 showed a highly selectivity response to H2O2 over other reactants such as reactive oxygen/nitrogen species, biothiols and various ions in aqueous solution at physiological pH. We have demonstrated that PB1 possesses an excellent response to H2O2 in the cells and in the brain tissue of drosophila from confocal fluorescence imaging. These results suggested that PB1 holds great potential in the study of the relationship between H2O2 overexpression and PD.

KW - Cell and tissue imaging

KW - Deep-red

KW - Hydrogen peroxide

KW - Parkinson's disease

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U2 - 10.1016/j.talanta.2019.03.017

DO - 10.1016/j.talanta.2019.03.017

M3 - 文章

C2 - 30952307

AN - SCOPUS:85062443594

SN - 0039-9140

VL - 199

SP - 628

EP - 633

JO - Talanta

JF - Talanta

ER -

A novel pyrimidine based deep-red fluorogenic probe for detecting hydrogen peroxide in Parkinson's disease models

Abstract

Keywords

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