A novel improved procedure for the synthesis of oxazoles

Wei Huang; Jian Pei; Bingzi Chen; Weiwei Pei; Xiulin Ye

doi:10.1016/0040-4020(96)00552-2

A novel improved procedure for the synthesis of oxazoles

Wei Huang, Jian Pei, Bingzi Chen, Weiwei Pei, Xiulin Ye

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

In the present work a novel improved and convenient procedure for the synthesis of oxazoles has been developed. Acetamide, instead of ammonium acetate, was used to react with phenacyl benzoates in boiling xylene in the presence of BF₃/Et₂O as the catalyst. According to this new synthetic route, nine oxazole compounds were readily prepared as single products in reasonably high yields. On the basis of the experimental results, a plausible mechanism of this reaction is proposed.

Original language	English
Pages (from-to)	10131-10136
Number of pages	6
Journal	Tetrahedron
Volume	52
Issue number	30
DOIs	https://doi.org/10.1016/0040-4020(96)00552-2
State	Published - 22 Jul 1996
Externally published	Yes

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title = "A novel improved procedure for the synthesis of oxazoles",

abstract = "In the present work a novel improved and convenient procedure for the synthesis of oxazoles has been developed. Acetamide, instead of ammonium acetate, was used to react with phenacyl benzoates in boiling xylene in the presence of BF3/Et2O as the catalyst. According to this new synthetic route, nine oxazole compounds were readily prepared as single products in reasonably high yields. On the basis of the experimental results, a plausible mechanism of this reaction is proposed.",

author = "Wei Huang and Jian Pei and Bingzi Chen and Weiwei Pei and Xiulin Ye",

year = "1996",

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T1 - A novel improved procedure for the synthesis of oxazoles

AU - Huang, Wei

AU - Pei, Jian

AU - Chen, Bingzi

AU - Pei, Weiwei

AU - Ye, Xiulin

PY - 1996/7/22

Y1 - 1996/7/22

N2 - In the present work a novel improved and convenient procedure for the synthesis of oxazoles has been developed. Acetamide, instead of ammonium acetate, was used to react with phenacyl benzoates in boiling xylene in the presence of BF3/Et2O as the catalyst. According to this new synthetic route, nine oxazole compounds were readily prepared as single products in reasonably high yields. On the basis of the experimental results, a plausible mechanism of this reaction is proposed.

AB - In the present work a novel improved and convenient procedure for the synthesis of oxazoles has been developed. Acetamide, instead of ammonium acetate, was used to react with phenacyl benzoates in boiling xylene in the presence of BF3/Et2O as the catalyst. According to this new synthetic route, nine oxazole compounds were readily prepared as single products in reasonably high yields. On the basis of the experimental results, a plausible mechanism of this reaction is proposed.

UR - http://www.scopus.com/inward/record.url?scp=15844372441&partnerID=8YFLogxK

U2 - 10.1016/0040-4020(96)00552-2

DO - 10.1016/0040-4020(96)00552-2

M3 - 文章

AN - SCOPUS:15844372441

SN - 0040-4020

VL - 52

SP - 10131

EP - 10136

JO - Tetrahedron

JF - Tetrahedron

IS - 30

ER -

A novel improved procedure for the synthesis of oxazoles

Abstract

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