A Flexible and Stretchable Kirigami-Inspired Implantable Neural Probe with Floating Microsites for Electrophysiology Recordings

Zhejun Guo; Bowen Ji; Longchun Wang; Bin Yang; Wei Wang; Jingquan Liu

doi:10.1109/MEMS46641.2020.9056263

A Flexible and Stretchable Kirigami-Inspired Implantable Neural Probe with Floating Microsites for Electrophysiology Recordings

Zhejun Guo, Bowen Ji, Longchun Wang, Bin Yang, Wei Wang, Jingquan Liu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

8 Scopus citations

Abstract

This paper reports on a flexible and stretchable neural probe based on polyimide (PI) which has excellent robustness and biocompatibility. For the first time, the kirigami structure is designed in the flexible probe substrate, and the composite Young's modulus of the flexible probe decreases from 2.5Gpa to 2KPa which will enhance adaptability of the probe in the micromotion of the brain tissue. Hundreds of cyclic stretching tests verified the flexibility and effectiveness of the neural probe. In addition, it has been proved in vitro that the probe can be easily implanted into the tissue by steel needle.

Original language	English
Title of host publication	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	350-353
Number of pages	4
ISBN (Electronic)	9781728135809
DOIs	https://doi.org/10.1109/MEMS46641.2020.9056263
State	Published - Jan 2020
Externally published	Yes
Event	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 - Vancouver, Canada Duration: 18 Jan 2020 → 22 Jan 2020

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2020-January
ISSN (Print)	1084-6999

Conference

Conference	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
Country/Territory	Canada
City	Vancouver
Period	18/01/20 → 22/01/20

Access to Document

10.1109/MEMS46641.2020.9056263

Cite this

Guo, Z., Ji, B., Wang, L., Yang, B., Wang, W., & Liu, J. (2020). A Flexible and Stretchable Kirigami-Inspired Implantable Neural Probe with Floating Microsites for Electrophysiology Recordings. In 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 (pp. 350-353). Article 9056263 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2020-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMS46641.2020.9056263

Guo, Zhejun ; Ji, Bowen ; Wang, Longchun et al. / A Flexible and Stretchable Kirigami-Inspired Implantable Neural Probe with Floating Microsites for Electrophysiology Recordings. 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. Institute of Electrical and Electronics Engineers Inc., 2020. pp. 350-353 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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title = "A Flexible and Stretchable Kirigami-Inspired Implantable Neural Probe with Floating Microsites for Electrophysiology Recordings",

abstract = "This paper reports on a flexible and stretchable neural probe based on polyimide (PI) which has excellent robustness and biocompatibility. For the first time, the kirigami structure is designed in the flexible probe substrate, and the composite Young's modulus of the flexible probe decreases from 2.5Gpa to 2KPa which will enhance adaptability of the probe in the micromotion of the brain tissue. Hundreds of cyclic stretching tests verified the flexibility and effectiveness of the neural probe. In addition, it has been proved in vitro that the probe can be easily implanted into the tissue by steel needle.",

author = "Zhejun Guo and Bowen Ji and Longchun Wang and Bin Yang and Wei Wang and Jingquan Liu",

note = "Publisher Copyright: {\textcopyright} 2020 IEEE.; 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 ; Conference date: 18-01-2020 Through 22-01-2020",

year = "2020",

month = jan,

doi = "10.1109/MEMS46641.2020.9056263",

language = "英语",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "350--353",

booktitle = "33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020",

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Guo, Z, Ji, B, Wang, L, Yang, B, Wang, W & Liu, J 2020, A Flexible and Stretchable Kirigami-Inspired Implantable Neural Probe with Floating Microsites for Electrophysiology Recordings. in 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020., 9056263, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2020-January, Institute of Electrical and Electronics Engineers Inc., pp. 350-353, 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020, Vancouver, Canada, 18/01/20. https://doi.org/10.1109/MEMS46641.2020.9056263

A Flexible and Stretchable Kirigami-Inspired Implantable Neural Probe with Floating Microsites for Electrophysiology Recordings. / Guo, Zhejun; Ji, Bowen; Wang, Longchun et al.
33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. Institute of Electrical and Electronics Engineers Inc., 2020. p. 350-353 9056263 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2020-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Wang, Wei

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AB - This paper reports on a flexible and stretchable neural probe based on polyimide (PI) which has excellent robustness and biocompatibility. For the first time, the kirigami structure is designed in the flexible probe substrate, and the composite Young's modulus of the flexible probe decreases from 2.5Gpa to 2KPa which will enhance adaptability of the probe in the micromotion of the brain tissue. Hundreds of cyclic stretching tests verified the flexibility and effectiveness of the neural probe. In addition, it has been proved in vitro that the probe can be easily implanted into the tissue by steel needle.

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Guo Z, Ji B, Wang L, Yang B, Wang W, Liu J. A Flexible and Stretchable Kirigami-Inspired Implantable Neural Probe with Floating Microsites for Electrophysiology Recordings. In 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. Institute of Electrical and Electronics Engineers Inc. 2020. p. 350-353. 9056263. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMS46641.2020.9056263

A Flexible and Stretchable Kirigami-Inspired Implantable Neural Probe with Floating Microsites for Electrophysiology Recordings

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