A dynamic skull model for simulation of cerebral cortex folding

Hanbo Chen; Lei Guo; Jingxin Nie; Tuo Zhang; Xintao Hu; Tianming Liu

doi:10.1007/978-3-642-15745-5_51

A dynamic skull model for simulation of cerebral cortex folding

Hanbo Chen, Lei Guo, Jingxin Nie, Tuo Zhang, Xintao Hu, Tianming Liu

School of Automation

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

12 Scopus citations

Abstract

The mechanisms of human cerebral cortex folding and their interactions during brain development are largely unknown, partly due to the difficulties in biological experiments and data acquisition for the developing fetus brain. Computational modeling and simulation provide a novel approach to the understanding of cortex folding processes in normal or aberrant neurodevelopment. Based on our recently developed computational model of the cerebral cortex folding using neuronal growth model and mechanical skull constraint, this paper presents a computational dynamic model of the brain skull that regulates the cortical folding simulation. Our simulation results show that the dynamic skull model is more biologically realistic and significantly improves our cortical folding simulation results. This work provides further computational support to the hypothesis that skull is an important regulator of cortical folding.

Original language	English
Title of host publication	Medical Image Computing and Computer-Assisted Intervention, MICCAI2010 - 13th International Conference, Proceedings
Pages	412-419
Number of pages	8
Edition	PART 2
DOIs	https://doi.org/10.1007/978-3-642-15745-5_51
State	Published - 2010
Event	13th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2010 - Beijing, China Duration: 20 Sep 2010 → 24 Sep 2010

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Number	PART 2
Volume	6362 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	13th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2010
Country/Territory	China
City	Beijing
Period	20/09/10 → 24/09/10

Keywords

Cortex Folding
Simulation
Skull Constraint

Access to Document

10.1007/978-3-642-15745-5_51

Cite this

Chen, H., Guo, L., Nie, J., Zhang, T., Hu, X., & Liu, T. (2010). A dynamic skull model for simulation of cerebral cortex folding. In Medical Image Computing and Computer-Assisted Intervention, MICCAI2010 - 13th International Conference, Proceedings (PART 2 ed., pp. 412-419). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6362 LNCS, No. PART 2). https://doi.org/10.1007/978-3-642-15745-5_51

Chen, Hanbo ; Guo, Lei ; Nie, Jingxin et al. / A dynamic skull model for simulation of cerebral cortex folding. Medical Image Computing and Computer-Assisted Intervention, MICCAI2010 - 13th International Conference, Proceedings. PART 2. ed. 2010. pp. 412-419 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 2).

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title = "A dynamic skull model for simulation of cerebral cortex folding",

abstract = "The mechanisms of human cerebral cortex folding and their interactions during brain development are largely unknown, partly due to the difficulties in biological experiments and data acquisition for the developing fetus brain. Computational modeling and simulation provide a novel approach to the understanding of cortex folding processes in normal or aberrant neurodevelopment. Based on our recently developed computational model of the cerebral cortex folding using neuronal growth model and mechanical skull constraint, this paper presents a computational dynamic model of the brain skull that regulates the cortical folding simulation. Our simulation results show that the dynamic skull model is more biologically realistic and significantly improves our cortical folding simulation results. This work provides further computational support to the hypothesis that skull is an important regulator of cortical folding.",

keywords = "Cortex Folding, Simulation, Skull Constraint",

author = "Hanbo Chen and Lei Guo and Jingxin Nie and Tuo Zhang and Xintao Hu and Tianming Liu",

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booktitle = "Medical Image Computing and Computer-Assisted Intervention, MICCAI2010 - 13th International Conference, Proceedings",

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Chen, H, Guo, L, Nie, J, Zhang, T, Hu, X & Liu, T 2010, A dynamic skull model for simulation of cerebral cortex folding. in Medical Image Computing and Computer-Assisted Intervention, MICCAI2010 - 13th International Conference, Proceedings. PART 2 edn, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), no. PART 2, vol. 6362 LNCS, pp. 412-419, 13th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2010, Beijing, China, 20/09/10. https://doi.org/10.1007/978-3-642-15745-5_51

A dynamic skull model for simulation of cerebral cortex folding. / Chen, Hanbo; Guo, Lei; Nie, Jingxin et al.
Medical Image Computing and Computer-Assisted Intervention, MICCAI2010 - 13th International Conference, Proceedings. PART 2. ed. 2010. p. 412-419 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6362 LNCS, No. PART 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - A dynamic skull model for simulation of cerebral cortex folding

AU - Chen, Hanbo

AU - Guo, Lei

AU - Nie, Jingxin

AU - Zhang, Tuo

AU - Hu, Xintao

AU - Liu, Tianming

PY - 2010

Y1 - 2010

N2 - The mechanisms of human cerebral cortex folding and their interactions during brain development are largely unknown, partly due to the difficulties in biological experiments and data acquisition for the developing fetus brain. Computational modeling and simulation provide a novel approach to the understanding of cortex folding processes in normal or aberrant neurodevelopment. Based on our recently developed computational model of the cerebral cortex folding using neuronal growth model and mechanical skull constraint, this paper presents a computational dynamic model of the brain skull that regulates the cortical folding simulation. Our simulation results show that the dynamic skull model is more biologically realistic and significantly improves our cortical folding simulation results. This work provides further computational support to the hypothesis that skull is an important regulator of cortical folding.

AB - The mechanisms of human cerebral cortex folding and their interactions during brain development are largely unknown, partly due to the difficulties in biological experiments and data acquisition for the developing fetus brain. Computational modeling and simulation provide a novel approach to the understanding of cortex folding processes in normal or aberrant neurodevelopment. Based on our recently developed computational model of the cerebral cortex folding using neuronal growth model and mechanical skull constraint, this paper presents a computational dynamic model of the brain skull that regulates the cortical folding simulation. Our simulation results show that the dynamic skull model is more biologically realistic and significantly improves our cortical folding simulation results. This work provides further computational support to the hypothesis that skull is an important regulator of cortical folding.

KW - Cortex Folding

KW - Simulation

KW - Skull Constraint

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Chen H, Guo L, Nie J, Zhang T, Hu X, Liu T. A dynamic skull model for simulation of cerebral cortex folding. In Medical Image Computing and Computer-Assisted Intervention, MICCAI2010 - 13th International Conference, Proceedings. PART 2 ed. 2010. p. 412-419. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 2). doi: 10.1007/978-3-642-15745-5_51

A dynamic skull model for simulation of cerebral cortex folding

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