TY - JOUR
T1 - Ultrasound-responsive BTO@MSN-Cu/chitosan coatings on titanium implants with synergistic antibacterial and angiogenic effects
AU - Jiang, Xiaodan
AU - Deng, Lechun
AU - Zhang, Yuhan
AU - Bao, Yuanqi
AU - Guo, Mingna
AU - Wu, Hongjing
AU - Chen, Qiang
N1 - Publisher Copyright:
© 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
PY - 2026/9
Y1 - 2026/9
N2 - Sonodynamic therapy (SDT) is a promising strategy for treating implant-associated infections (IAIs), yet achieving concurrent antibacterial efficacy and tissue regeneration remains challenging. In this study, piezoelectric BaTiO3 (BTO) nanoparticles were encapsulated within Cu-doped mesoporous silica (MSN) via a sol-gel method to construct core-shell BTO@MSN-Cu nanoparticles, which were subsequently electrophoretically co-deposited with chitosan onto titanium (Ti) substrates to form a multifunctional coating. Under ultrasound (US) irradiation, the BTO core generated reactive oxygen species (ROS) via piezocatalysis, while the MSN shell enabled controlled and stimulus-responsive release of Cu ions. Theoretical calculations revealed that the core-shell heterostructure enhances piezoelectric potential and charge separation. The resulting coating exhibited potent antibacterial efficiency (>99% against S. aureus, >95% against E. coli), while also supporting osteoblast adhesion and proliferation and enhancing endothelial cell migration and angiogenesis. Overall, this chitosan/BTO@MSN-Cu coating integrates US-activated sonodynamic action and Cu ion therapy to provide a dual-modal strategy for infection control and tissue repair in IAIs.
AB - Sonodynamic therapy (SDT) is a promising strategy for treating implant-associated infections (IAIs), yet achieving concurrent antibacterial efficacy and tissue regeneration remains challenging. In this study, piezoelectric BaTiO3 (BTO) nanoparticles were encapsulated within Cu-doped mesoporous silica (MSN) via a sol-gel method to construct core-shell BTO@MSN-Cu nanoparticles, which were subsequently electrophoretically co-deposited with chitosan onto titanium (Ti) substrates to form a multifunctional coating. Under ultrasound (US) irradiation, the BTO core generated reactive oxygen species (ROS) via piezocatalysis, while the MSN shell enabled controlled and stimulus-responsive release of Cu ions. Theoretical calculations revealed that the core-shell heterostructure enhances piezoelectric potential and charge separation. The resulting coating exhibited potent antibacterial efficiency (>99% against S. aureus, >95% against E. coli), while also supporting osteoblast adhesion and proliferation and enhancing endothelial cell migration and angiogenesis. Overall, this chitosan/BTO@MSN-Cu coating integrates US-activated sonodynamic action and Cu ion therapy to provide a dual-modal strategy for infection control and tissue repair in IAIs.
KW - Angiogenesis
KW - Core-shell structure
KW - Multi-antibacterial property
KW - Sonodynamic therapy
KW - Surface modification
UR - https://www.scopus.com/pages/publications/105037149748
U2 - 10.1016/j.colsurfb.2026.115759
DO - 10.1016/j.colsurfb.2026.115759
M3 - 文章
AN - SCOPUS:105037149748
SN - 0927-7765
VL - 265
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
M1 - 115759
ER -