Super-resolution reconstruction of neonatal brain magnetic resonance images via residual structured sparse representation

Magnetic resonance images of neonates, compared with toddlers, exhibit lower signal-to-noise ratio and spatial resolution. In this paper, we propose a novel method for super-resolution reconstruction of neonate images with the help of toddler images, using residual-structured sparse representation with convex regularization. Specifically, we introduce a two-layer image representation, consisting of a base layer and a detail layer, to cater to signal variation across scanners and sites. The base layer consists of the smoothed version of the image obtained via Gaussian filtering. The detail layer is the difference between the original image and the base layer. High-frequency details in the detail layer are borrowed across subjects for super-resolution reconstruction. Experimental results on T1 and T2 images demonstrate that the proposed algorithm can recover fine anatomical structures, and generally outperform the state-of-the-art methods both qualitatively and quantitatively.