Study on the affinities of antagonistic peptides with HAb18G/CD147 on the hepatocellular carcinoma cells

Ai Rong Qian; Peng Shang; Yu Li; Chun Mei Fan; Dan Chen; Chun Mei Wang; Ping Zhu; Zhi Nan Chen

Study on the affinities of antagonistic peptides with HAb18G/CD147 on the hepatocellular carcinoma cells

Ai Rong Qian
, Peng Shang
, Yu Li
, Chun Mei Fan
, Dan Chen
, Chun Mei Wang
, Ping Zhu
, Zhi Nan Chen

Air Force Medical University

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

AIM: To study the affinities of antagonistic peptides with HAb18G/CD147 on the hepatocellular carcinoma cells.

METHODS: Fluorescence-activated cell sorting analysis(FACS) was used to detect the expression of HAb18G antigen on HHCC and SMMC7721 cells. Antagonistic peptides(APs) AP-1, AP-2 and AP-6 were labelled with biotin at their N-terminals. The binding abilities of APs to HHCC or SMMC7721 cells were determined by FACS and confocal microscope.

RESULTS: HAb18G antigen was highly expressed on the HHCC and SMMC7721 cells. AP-6 has the highest affinity for HHCC and SMMC7721 cells compared with AP-1 and AP-2.

CONCLUSION: Antagonistic peptides of HAb18G/CD147 have high affinities with HAb18G/CD147 on the hepatocellular carcinoma cells.

源语言	英语
页（从-至）	127-129
页数	3
期刊	Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
卷	19
期	2
出版状态	已出版 - 1 3月 2003
已对外发布	是

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{98fbd763260247e4b621f961012ad1fd,

title = "Study on the affinities of antagonistic peptides with HAb18G/CD147 on the hepatocellular carcinoma cells",

abstract = "AIM: To study the affinities of antagonistic peptides with HAb18G/CD147 on the hepatocellular carcinoma cells.METHODS: Fluorescence-activated cell sorting analysis(FACS) was used to detect the expression of HAb18G antigen on HHCC and SMMC7721 cells. Antagonistic peptides(APs) AP-1, AP-2 and AP-6 were labelled with biotin at their N-terminals. The binding abilities of APs to HHCC or SMMC7721 cells were determined by FACS and confocal microscope.RESULTS: HAb18G antigen was highly expressed on the HHCC and SMMC7721 cells. AP-6 has the highest affinity for HHCC and SMMC7721 cells compared with AP-1 and AP-2.CONCLUSION: Antagonistic peptides of HAb18G/CD147 have high affinities with HAb18G/CD147 on the hepatocellular carcinoma cells.",

author = "Qian, \{Ai Rong\} and Peng Shang and Yu Li and Fan, \{Chun Mei\} and Dan Chen and Wang, \{Chun Mei\} and Ping Zhu and Chen, \{Zhi Nan\}",

year = "2003",

month = mar,

day = "1",

language = "英语",

volume = "19",

pages = "127--129",

journal = "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology",

issn = "1007-8738",

publisher = "Fourth Military Medical University",

number = "2",

}

TY - JOUR

T1 - Study on the affinities of antagonistic peptides with HAb18G/CD147 on the hepatocellular carcinoma cells

AU - Qian, Ai Rong

AU - Shang, Peng

AU - Li, Yu

AU - Fan, Chun Mei

AU - Chen, Dan

AU - Wang, Chun Mei

AU - Zhu, Ping

AU - Chen, Zhi Nan

PY - 2003/3/1

Y1 - 2003/3/1

N2 - AIM: To study the affinities of antagonistic peptides with HAb18G/CD147 on the hepatocellular carcinoma cells.METHODS: Fluorescence-activated cell sorting analysis(FACS) was used to detect the expression of HAb18G antigen on HHCC and SMMC7721 cells. Antagonistic peptides(APs) AP-1, AP-2 and AP-6 were labelled with biotin at their N-terminals. The binding abilities of APs to HHCC or SMMC7721 cells were determined by FACS and confocal microscope.RESULTS: HAb18G antigen was highly expressed on the HHCC and SMMC7721 cells. AP-6 has the highest affinity for HHCC and SMMC7721 cells compared with AP-1 and AP-2.CONCLUSION: Antagonistic peptides of HAb18G/CD147 have high affinities with HAb18G/CD147 on the hepatocellular carcinoma cells.

AB - AIM: To study the affinities of antagonistic peptides with HAb18G/CD147 on the hepatocellular carcinoma cells.METHODS: Fluorescence-activated cell sorting analysis(FACS) was used to detect the expression of HAb18G antigen on HHCC and SMMC7721 cells. Antagonistic peptides(APs) AP-1, AP-2 and AP-6 were labelled with biotin at their N-terminals. The binding abilities of APs to HHCC or SMMC7721 cells were determined by FACS and confocal microscope.RESULTS: HAb18G antigen was highly expressed on the HHCC and SMMC7721 cells. AP-6 has the highest affinity for HHCC and SMMC7721 cells compared with AP-1 and AP-2.CONCLUSION: Antagonistic peptides of HAb18G/CD147 have high affinities with HAb18G/CD147 on the hepatocellular carcinoma cells.

UR - https://www.scopus.com/pages/publications/84983050265

M3 - 文章

C2 - 15151746

AN - SCOPUS:84983050265

SN - 1007-8738

VL - 19

SP - 127

EP - 129

JO - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

JF - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

IS - 2

ER -

Study on the affinities of antagonistic peptides with HAb18G/CD147 on the hepatocellular carcinoma cells

摘要

其它文件与链接

指纹

引用此