Role of Wnt signaling in fracture healing

Huiyun Xu; Jing Duan; Dandan Ning; Jingbao Li; Ruofei Liu; Ruixin Yang; Jean X. Jiang; Peng Shang

doi:10.5483/BMBRep.2014.47.12.193

Role of Wnt signaling in fracture healing

Huiyun Xu
, Jing Duan
, Dandan Ning
, Jingbao Li
, Ruofei Liu
, Ruixin Yang
, Jean X. Jiang
, Peng Shang

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45 引用（Scopus）

摘要

The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent research progress in the area, which may be conducive to the development of Wnt-based therapeutic strategies for bone repair.

源语言	英语
页（从-至）	666-672
页数	7
期刊	BMB Reports
卷	47
期	12
DOI	https://doi.org/10.5483/BMBRep.2014.47.12.193
出版状态	已出版 - 2014

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title = "Role of Wnt signaling in fracture healing",

abstract = "The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent research progress in the area, which may be conducive to the development of Wnt-based therapeutic strategies for bone repair.",

keywords = "Fracture healing, GSK-3β, Sost, Wnt signaling pathway, β-catenin",

author = "Huiyun Xu and Jing Duan and Dandan Ning and Jingbao Li and Ruofei Liu and Ruixin Yang and Jiang, \{Jean X.\} and Peng Shang",

note = "Publisher Copyright: {\textcopyright} 2014 by the The Korean Society for Biochemistry and Molecular Biology.",

year = "2014",

doi = "10.5483/BMBRep.2014.47.12.193",

language = "英语",

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AU - Xu, Huiyun

AU - Duan, Jing

AU - Ning, Dandan

AU - Li, Jingbao

AU - Liu, Ruofei

AU - Yang, Ruixin

AU - Jiang, Jean X.

AU - Shang, Peng

PY - 2014

Y1 - 2014

N2 - The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent research progress in the area, which may be conducive to the development of Wnt-based therapeutic strategies for bone repair.

AB - The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent research progress in the area, which may be conducive to the development of Wnt-based therapeutic strategies for bone repair.

KW - Fracture healing

KW - GSK-3β

KW - Sost

KW - Wnt signaling pathway

KW - β-catenin

UR - https://www.scopus.com/pages/publications/84922334375

U2 - 10.5483/BMBRep.2014.47.12.193

DO - 10.5483/BMBRep.2014.47.12.193

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IS - 12

ER -

Role of Wnt signaling in fracture healing

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