Preparation of functionalized double ratio fluorescent imprinted sensors for visual determination and recognition of dopamine in human serum

Ratiometric fluorescent sensors have shown great prospect in chemical monitoring and recognition due to its high intuitiveness, accurateness, and visualization. In this work, the ratiometric fluorescent sensors, which includes a blue fluorescent Carbon quantum dots (CQDs)as internal standard material, and a red fluorescent boric acid-modified CdTe QDs as response signal. Then we choose dopamine (DA)as template, 3-phenylboronic acid (APBA)for functional monomers, tetraethyl orthosilicate (TEOS)for cross-linker to synthesize double ratio molecularly imprinted polymers (DR-MIPs)that can identify dopamine selectively and sensitively. The DR-MIPs has better capability of selective recognition, obvious anti-ion interference, rapid detection and good visualization. Furthermore, the unique DR-MIPs was proved as efficient visual sensors for determination of DA in human serum rapidly and efficiently. The DR-MIPs still displayed well accuracy, and the potential prospects of this smart sensor is clearly demonstrated in the context of modern clinical medicine.