@inbook{e5cee1ed1c574c2d9c8e2f892b422ab3,
title = "Polyvinylamine and Its Derivative as Effective Carrier for Targeted Delivery of Small RNAs",
abstract = "Polymeric delivery systems could enable the fast- and low-side-effect transport of various RNA classes. Previously, we demonstrated that polyvinylamine (PVAm), a cationic polymer, transfects many kinds of RNAs with high efficiency and low toxicity both in vitro and in vivo. The modification of poly lactic-co-glycolic acid (PLGA) with cartilage-targeting peptide (CAP) enhances its stiffness and tissue-specific delivery of RNA to overcome the avascular nature of articular cartilage. Here we describe the protocol to use PVAm as an RNA carrier, and further, by modifying PVAm with PLGA and CAP, the corresponding co-polymer could be applied for functional RNA delivery for osteoarthritis treatment.",
keywords = "CAP-PVAm-PLGA, Cartilage-targeting, In vitro and in vivo, PVAm, RNA delivery system",
author = "Ye Tian and Suryaji Patil and Xudong Deng and Yipu Zhao and Bo Sang and Airong Qian",
note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024.",
year = "2024",
doi = "10.1007/978-1-0716-3918-4\_22",
language = "英语",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "353--365",
booktitle = "Methods in Molecular Biology",
}