TY - JOUR
T1 - Novel Biomedical Functions of Surfactin A from Bacillus subtilis in Wound Healing Promotion and Scar Inhibition
AU - Yan, Lu
AU - Liu, Guanwen
AU - Zhao, Bin
AU - Pang, Bing
AU - Wu, Wanqin
AU - Ai, Chongyang
AU - Zhao, Xixi
AU - Wang, Xinglong
AU - Jiang, Chunmei
AU - Shao, Dongyan
AU - Liu, Qianlong
AU - Li, Meixuan
AU - Wang, Lei
AU - Shi, Junling
N1 - Publisher Copyright:
© 2020 American Chemical Society.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Surfactin produced by Bacillus subtilis is a powerful biosurfactant in food, cosmetics, and pesticide industries. However, its suitability in wound healing applications is uncertain. In this article, we determined the effects of surfactin A from B. subtilis on wound healing, angiogenesis, cell migration, inflammatory response, and scar formation. The results indicated that 80.65 ± 2.03% of surfactin A-treated wounds were closed, whereas 44.30 ± 4.26% of the vehicle-treated wound areas remained open on day 7 (P < 0.05). In mechanisms, it upregulated the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF), accelerated keratinocyte migration through mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathways, and regulated the secretion of proinflammatory cytokines and macrophage phenotypic switch. More attractive, surfactin A showed a seductive capability to inhibit scar tissue formation by affecting the expression of α-smooth muscle actin (α-SMA) and transforming growth factor (TGF-β). Overall, the study revealed a new function and potential of surfactin A as an affordable and efficient wound healing drug.
AB - Surfactin produced by Bacillus subtilis is a powerful biosurfactant in food, cosmetics, and pesticide industries. However, its suitability in wound healing applications is uncertain. In this article, we determined the effects of surfactin A from B. subtilis on wound healing, angiogenesis, cell migration, inflammatory response, and scar formation. The results indicated that 80.65 ± 2.03% of surfactin A-treated wounds were closed, whereas 44.30 ± 4.26% of the vehicle-treated wound areas remained open on day 7 (P < 0.05). In mechanisms, it upregulated the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF), accelerated keratinocyte migration through mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathways, and regulated the secretion of proinflammatory cytokines and macrophage phenotypic switch. More attractive, surfactin A showed a seductive capability to inhibit scar tissue formation by affecting the expression of α-smooth muscle actin (α-SMA) and transforming growth factor (TGF-β). Overall, the study revealed a new function and potential of surfactin A as an affordable and efficient wound healing drug.
KW - Bacillus subtilis
KW - cell migration
KW - scar inhibition
KW - surfactin A
KW - wound healing
UR - https://www.scopus.com/pages/publications/85087465926
U2 - 10.1021/acs.jafc.0c01658
DO - 10.1021/acs.jafc.0c01658
M3 - 文章
C2 - 32412748
AN - SCOPUS:85087465926
SN - 0021-8561
VL - 68
SP - 6987
EP - 6997
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
IS - 26
ER -