TY - JOUR
T1 - High-performance microcalorimeters
T2 - Design, applications and future development
AU - Feng, Jianguo
AU - Svatoš, Vojtěch
AU - Liu, Xiaocheng
AU - Chang, Honglong
AU - Neužil, Pavel
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/12
Y1 - 2018/12
N2 - Microcalorimetry has been widely used to measure and characterize the heat change in phase transition, resolution mixing, and chemical/biochemical reactions. In this review, we discuss progress in the development of high-performance microfabricated calorimeters starting with their design, fluid handling, and temperature measurement. The considerations of chip design are highlighted. Then, a few representative applications are introduced and their chip parameters and properties are compared. Finally, trends and prospects of microcalorimeters for high-performance applications, such as enthalpy measurements in minute volumes of chemicals suitable for drug discovery as well as bio-applications in energy balance monitoring of living cells and investigation of their thermogenesis, are discussed.
AB - Microcalorimetry has been widely used to measure and characterize the heat change in phase transition, resolution mixing, and chemical/biochemical reactions. In this review, we discuss progress in the development of high-performance microfabricated calorimeters starting with their design, fluid handling, and temperature measurement. The considerations of chip design are highlighted. Then, a few representative applications are introduced and their chip parameters and properties are compared. Finally, trends and prospects of microcalorimeters for high-performance applications, such as enthalpy measurements in minute volumes of chemicals suitable for drug discovery as well as bio-applications in energy balance monitoring of living cells and investigation of their thermogenesis, are discussed.
KW - Analytical and bioanalytical chemistry
KW - Cell biology monitoring
KW - Fluid handling
KW - High performance
KW - Microcalorimeter
KW - Microelectromechanical system
KW - Temperature sensing
KW - Thermal isolation
KW - Thermodynamic characterization
UR - https://www.scopus.com/pages/publications/85054587529
U2 - 10.1016/j.trac.2018.09.017
DO - 10.1016/j.trac.2018.09.017
M3 - 文献综述
AN - SCOPUS:85054587529
SN - 0165-9936
VL - 109
SP - 43
EP - 49
JO - TrAC - Trends in Analytical Chemistry
JF - TrAC - Trends in Analytical Chemistry
ER -