Engineering Melanin Nanoparticles as an Efficient Drug-Delivery System for Imaging-Guided Chemotherapy

Ruiping Zhang; Quli Fan; Min Yang; Kai Cheng; Xiaomei Lu; Lei Zhang; Wei Huang; Zhen Cheng

doi:10.1002/adma.201502201

Engineering Melanin Nanoparticles as an Efficient Drug-Delivery System for Imaging-Guided Chemotherapy

Ruiping Zhang
, Quli Fan
, Min Yang
, Kai Cheng
, Xiaomei Lu
, Lei Zhang
, Wei Huang
, Zhen Cheng

Shanxi Medical University
Stanford University
Nanjing University of Posts and Telecommunications
Ministry of Health of People's Republic of China

科研成果: 期刊稿件 › 文章 › 同行评审

187 引用（Scopus）

摘要

In order to promote imaging-guided chemotherapy for preclinical and clinical applications, endogenous nanosystems with both contrast and drug-delivery properties are highly desired. Here, the simple use of melanin is first reported, and this biopolymer with good biocompatibility and biodegradability, binding ability to drugs and ions, and intrinsic photoacoustic properties, can serve as an efficient endogenous nanosystem for imaging-guided tumor chemotherapy in living mice.

源语言	英语
页（从-至）	5063-5069
页数	7
期刊	Advanced Materials
卷	27
期	34
DOI	https://doi.org/10.1002/adma.201502201
出版状态	已出版 - 1 9月 2015
已对外发布	是

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title = "Engineering Melanin Nanoparticles as an Efficient Drug-Delivery System for Imaging-Guided Chemotherapy",

abstract = "In order to promote imaging-guided chemotherapy for preclinical and clinical applications, endogenous nanosystems with both contrast and drug-delivery properties are highly desired. Here, the simple use of melanin is first reported, and this biopolymer with good biocompatibility and biodegradability, binding ability to drugs and ions, and intrinsic photoacoustic properties, can serve as an efficient endogenous nanosystem for imaging-guided tumor chemotherapy in living mice.",

keywords = "drug delivery, melanin nanoparticles, photoacoustic imaging, positron emission tomography (PET), sorafenib",

author = "Ruiping Zhang and Quli Fan and Min Yang and Kai Cheng and Xiaomei Lu and Lei Zhang and Wei Huang and Zhen Cheng",

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T1 - Engineering Melanin Nanoparticles as an Efficient Drug-Delivery System for Imaging-Guided Chemotherapy

AU - Zhang, Ruiping

AU - Fan, Quli

AU - Yang, Min

AU - Cheng, Kai

AU - Lu, Xiaomei

AU - Zhang, Lei

AU - Huang, Wei

AU - Cheng, Zhen

PY - 2015/9/1

Y1 - 2015/9/1

N2 - In order to promote imaging-guided chemotherapy for preclinical and clinical applications, endogenous nanosystems with both contrast and drug-delivery properties are highly desired. Here, the simple use of melanin is first reported, and this biopolymer with good biocompatibility and biodegradability, binding ability to drugs and ions, and intrinsic photoacoustic properties, can serve as an efficient endogenous nanosystem for imaging-guided tumor chemotherapy in living mice.

AB - In order to promote imaging-guided chemotherapy for preclinical and clinical applications, endogenous nanosystems with both contrast and drug-delivery properties are highly desired. Here, the simple use of melanin is first reported, and this biopolymer with good biocompatibility and biodegradability, binding ability to drugs and ions, and intrinsic photoacoustic properties, can serve as an efficient endogenous nanosystem for imaging-guided tumor chemotherapy in living mice.

KW - drug delivery

KW - melanin nanoparticles

KW - photoacoustic imaging

KW - positron emission tomography (PET)

KW - sorafenib

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JO - Advanced Materials

JF - Advanced Materials

IS - 34

ER -

Engineering Melanin Nanoparticles as an Efficient Drug-Delivery System for Imaging-Guided Chemotherapy

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