Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

Wenbo Hu; Hengheng Ma; Bing Hou; Hui Zhao; Yu Ji; Rongcui Jiang; Xiaoming Hu; Xiaomei Lu; Lei Zhang; Yufu Tang; Quli Fan; Wei Huang

doi:10.1021/acsami.6b02721

Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

Wenbo Hu
, Hengheng Ma
, Bing Hou
, Hui Zhao
, Yu Ji
, Rongcui Jiang
, Xiaoming Hu
, Xiaomei Lu
, Lei Zhang
, Yufu Tang
, Quli Fan
, Wei Huang

Nanjing University of Posts and Telecommunications
Nanjing Tech University

科研成果: 期刊稿件 › 文章 › 同行评审

137 引用（Scopus）

摘要

Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.

源语言	英语
页（从-至）	12039-12047
页数	9
期刊	ACS Applied Materials and Interfaces
卷	8
期	19
DOI	https://doi.org/10.1021/acsami.6b02721
出版状态	已出版 - 18 5月 2016
已对外发布	是

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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10.1021/acsami.6b02721

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title = "Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light",

abstract = "Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.",

keywords = "lysosome-targeting, near-infrared absorption, photoacoustic imaging, photodynamic therapy, theranostic nanoparticles",

author = "Wenbo Hu and Hengheng Ma and Bing Hou and Hui Zhao and Yu Ji and Rongcui Jiang and Xiaoming Hu and Xiaomei Lu and Lei Zhang and Yufu Tang and Quli Fan and Wei Huang",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

month = may,

day = "18",

doi = "10.1021/acsami.6b02721",

language = "英语",

volume = "8",

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journal = "ACS Applied Materials and Interfaces",

issn = "1944-8244",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

AU - Hu, Wenbo

AU - Ma, Hengheng

AU - Hou, Bing

AU - Zhao, Hui

AU - Ji, Yu

AU - Jiang, Rongcui

AU - Hu, Xiaoming

AU - Lu, Xiaomei

AU - Zhang, Lei

AU - Tang, Yufu

AU - Fan, Quli

AU - Huang, Wei

PY - 2016/5/18

Y1 - 2016/5/18

N2 - Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.

AB - Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.

KW - lysosome-targeting

KW - near-infrared absorption

KW - photoacoustic imaging

KW - photodynamic therapy

KW - theranostic nanoparticles

UR - https://www.scopus.com/pages/publications/84971264957

U2 - 10.1021/acsami.6b02721

DO - 10.1021/acsami.6b02721

M3 - 文章

C2 - 27123534

AN - SCOPUS:84971264957

SN - 1944-8244

VL - 8

SP - 12039

EP - 12047

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 19

ER -

Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

摘要

联合国可持续发展目标

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