TY - JOUR
T1 - Effect of Hydrophilic Monomer Distribution on Self-Assembly of a pH-Responsive Copolymer
T2 - Spheres, Worms and Vesicles from a Single Copolymer Composition
AU - Zhang, Junliang
AU - Farias-Mancilla, Barbara
AU - Kulai, Ihor
AU - Hoeppener, Stephanie
AU - Lonetti, Barbara
AU - Prévost, Sylvain
AU - Ulbrich, Jens
AU - Destarac, Mathias
AU - Colombani, Olivier
AU - Schubert, Ulrich S.
AU - Guerrero-Sanchez, Carlos
AU - Harrisson, Simon
N1 - Publisher Copyright:
© 2020 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH
PY - 2021/2/23
Y1 - 2021/2/23
N2 - A series of copolymers containing 50 mol % acrylic acid (AA) and 50 mol % butyl acrylate (BA) but with differing composition profiles ranging from an AA-BA diblock copolymer to a linear gradient poly(AA-grad-BA) copolymer were synthesized and their pH-responsive self-assembly behavior was investigated. While assemblies of the AA-BA diblock copolymer were kinetically frozen, the gradient-like compositions underwent reversible changes in size and morphology in response to changes in pH. In particular, a diblock copolymer consisting of two random copolymer segments of equal length (16 mol % and 84 mol % AA content, respectively) formed spherical micelles at pH >5, a mix of spherical and wormlike micelles at pH 5 and vesicles at pH 4. These assemblies were characterized by dynamic light scattering, cryo-transmission electron microscopy and small angle neutron scattering.
AB - A series of copolymers containing 50 mol % acrylic acid (AA) and 50 mol % butyl acrylate (BA) but with differing composition profiles ranging from an AA-BA diblock copolymer to a linear gradient poly(AA-grad-BA) copolymer were synthesized and their pH-responsive self-assembly behavior was investigated. While assemblies of the AA-BA diblock copolymer were kinetically frozen, the gradient-like compositions underwent reversible changes in size and morphology in response to changes in pH. In particular, a diblock copolymer consisting of two random copolymer segments of equal length (16 mol % and 84 mol % AA content, respectively) formed spherical micelles at pH >5, a mix of spherical and wormlike micelles at pH 5 and vesicles at pH 4. These assemblies were characterized by dynamic light scattering, cryo-transmission electron microscopy and small angle neutron scattering.
KW - copolymer
KW - gradient copolymer
KW - self-assembly
KW - sequence control
KW - stimuli-responsive
UR - https://www.scopus.com/pages/publications/85096670509
U2 - 10.1002/anie.202010501
DO - 10.1002/anie.202010501
M3 - 文章
C2 - 32997426
AN - SCOPUS:85096670509
SN - 1433-7851
VL - 60
SP - 4925
EP - 4930
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 9
ER -