Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

Weining Niu; Ping Wu; Fei Chen; Jun Wang; Xiaoya Shang; Chunlan Xu

doi:10.1039/c6md00493h

Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

Weining Niu
, Ping Wu
, Fei Chen
, Jun Wang
, Xiaoya Shang
, Chunlan Xu

生命学院

Northwestern Polytechnical University Xian

科研成果: 期刊稿件 › 文章 › 同行评审

27 引用（Scopus）

摘要

A high-throughput assay was developed to identify inhibitors of cystathionine β-synthase (CBS), which is one of three key enzymes involved in H₂S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells, with IC₅₀ values of less than 10 μM.

源语言	英语
页（从-至）	198-201
页数	4
期刊	MedChemComm
卷	8
期	1
DOI	https://doi.org/10.1039/c6md00493h
出版状态	已出版 - 2017

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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10.1039/c6md00493h

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引用此

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title = "Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe",

abstract = "A high-throughput assay was developed to identify inhibitors of cystathionine β-synthase (CBS), which is one of three key enzymes involved in H2S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells, with IC50 values of less than 10 μM.",

author = "Weining Niu and Ping Wu and Fei Chen and Jun Wang and Xiaoya Shang and Chunlan Xu",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2017",

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AU - Niu, Weining

AU - Wu, Ping

AU - Chen, Fei

AU - Wang, Jun

AU - Shang, Xiaoya

AU - Xu, Chunlan

PY - 2017

Y1 - 2017

N2 - A high-throughput assay was developed to identify inhibitors of cystathionine β-synthase (CBS), which is one of three key enzymes involved in H2S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells, with IC50 values of less than 10 μM.

AB - A high-throughput assay was developed to identify inhibitors of cystathionine β-synthase (CBS), which is one of three key enzymes involved in H2S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells, with IC50 values of less than 10 μM.

UR - https://www.scopus.com/pages/publications/85010766695

U2 - 10.1039/c6md00493h

DO - 10.1039/c6md00493h

M3 - 文章

AN - SCOPUS:85010766695

SN - 2040-2503

VL - 8

SP - 198

EP - 201

JO - MedChemComm

JF - MedChemComm

IS - 1

ER -

Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

摘要

联合国可持续发展目标

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其它文件与链接

学术指纹

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