Chemiluminescent organic nanophotosensitizer for a penetration depth independent photodynamic therapy

Xiaomei Lu; Xingwen Song; Qi Wang; Wenbo Hu; Wei Shi; Yufu Tang; Zizi Wu; Quli Fan; Wei Huang

doi:10.1039/d0ra01477j

Chemiluminescent organic nanophotosensitizer for a penetration depth independent photodynamic therapy

Xiaomei Lu
, Xingwen Song
, Qi Wang
, Wenbo Hu
, Wei Shi
, Yufu Tang
, Zizi Wu
, Quli Fan
, Wei Huang

柔性电子研究院

Nanjing Tech University
Nanjing University of Posts and Telecommunications

科研成果: 期刊稿件 › 文章 › 同行评审

10 引用（Scopus）

摘要

Photodynamic therapy initiated by external photoexcitation is a clinically-approved therapeutic paradigm, but its practical application has been severely hindered by the shallow penetration of light. Here, we describe a penetration-independent PDT modality using a chemiluminescent organic nanophotosensitizer, which is activated by hydrogen peroxide instead of external photoexcitation.

源语言	英语
页（从-至）	11861-11864
页数	4
期刊	RSC Advances
卷	10
期	20
DOI	https://doi.org/10.1039/d0ra01477j
出版状态	已出版 - 24 3月 2020

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10.1039/d0ra01477j

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abstract = "Photodynamic therapy initiated by external photoexcitation is a clinically-approved therapeutic paradigm, but its practical application has been severely hindered by the shallow penetration of light. Here, we describe a penetration-independent PDT modality using a chemiluminescent organic nanophotosensitizer, which is activated by hydrogen peroxide instead of external photoexcitation.",

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AU - Lu, Xiaomei

AU - Song, Xingwen

AU - Wang, Qi

AU - Hu, Wenbo

AU - Shi, Wei

AU - Tang, Yufu

AU - Wu, Zizi

AU - Fan, Quli

AU - Huang, Wei

PY - 2020/3/24

Y1 - 2020/3/24

N2 - Photodynamic therapy initiated by external photoexcitation is a clinically-approved therapeutic paradigm, but its practical application has been severely hindered by the shallow penetration of light. Here, we describe a penetration-independent PDT modality using a chemiluminescent organic nanophotosensitizer, which is activated by hydrogen peroxide instead of external photoexcitation.

AB - Photodynamic therapy initiated by external photoexcitation is a clinically-approved therapeutic paradigm, but its practical application has been severely hindered by the shallow penetration of light. Here, we describe a penetration-independent PDT modality using a chemiluminescent organic nanophotosensitizer, which is activated by hydrogen peroxide instead of external photoexcitation.

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U2 - 10.1039/d0ra01477j

DO - 10.1039/d0ra01477j

M3 - 文章

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VL - 10

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JO - RSC Advances

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Chemiluminescent organic nanophotosensitizer for a penetration depth independent photodynamic therapy

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