Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy

Yu Cai; Qianyun Tang; Xiujuan Wu; Weili Si; Qi Zhang; Wei Huang; Xiaochen Dong

doi:10.1021/acsami.6b01533

Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy

Yu Cai
, Qianyun Tang
, Xiujuan Wu
, Weili Si
, Qi Zhang
, Wei Huang
, Xiaochen Dong

Nanjing Tech University

科研成果: 期刊稿件 › 文章 › 同行评审

79 引用（Scopus）

摘要

Novel photosensitizers with high reactive oxygen species generation and precise targeting to tumors are crucial for photodynamic therapy (PDT). Here, a bromo-substituted diketopyrrolopyrrole derivative (2,5-bis(6-bromohexyl)-3,6-bis(5-bromothiophene-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione)-grafted hyaluronic acid is synthesized, which presents excellent targeting and PDT efficiency both in vitro and in vivo.

源语言	英语
页（从-至）	10737-10742
页数	6
期刊	ACS Applied Materials and Interfaces
卷	8
期	17
DOI	https://doi.org/10.1021/acsami.6b01533
出版状态	已出版 - 4 5月 2016
已对外发布	是

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title = "Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy",

abstract = "Novel photosensitizers with high reactive oxygen species generation and precise targeting to tumors are crucial for photodynamic therapy (PDT). Here, a bromo-substituted diketopyrrolopyrrole derivative (2,5-bis(6-bromohexyl)-3,6-bis(5-bromothiophene-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione)-grafted hyaluronic acid is synthesized, which presents excellent targeting and PDT efficiency both in vitro and in vivo.",

keywords = "bromo-substituted, diketopyrrolopyrrole, hyaluronic acid, photodynamic therapy, photosensitizers",

author = "Yu Cai and Qianyun Tang and Xiujuan Wu and Weili Si and Qi Zhang and Wei Huang and Xiaochen Dong",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

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doi = "10.1021/acsami.6b01533",

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T1 - Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy

AU - Cai, Yu

AU - Tang, Qianyun

AU - Wu, Xiujuan

AU - Si, Weili

AU - Zhang, Qi

AU - Huang, Wei

AU - Dong, Xiaochen

PY - 2016/5/4

Y1 - 2016/5/4

N2 - Novel photosensitizers with high reactive oxygen species generation and precise targeting to tumors are crucial for photodynamic therapy (PDT). Here, a bromo-substituted diketopyrrolopyrrole derivative (2,5-bis(6-bromohexyl)-3,6-bis(5-bromothiophene-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione)-grafted hyaluronic acid is synthesized, which presents excellent targeting and PDT efficiency both in vitro and in vivo.

AB - Novel photosensitizers with high reactive oxygen species generation and precise targeting to tumors are crucial for photodynamic therapy (PDT). Here, a bromo-substituted diketopyrrolopyrrole derivative (2,5-bis(6-bromohexyl)-3,6-bis(5-bromothiophene-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione)-grafted hyaluronic acid is synthesized, which presents excellent targeting and PDT efficiency both in vitro and in vivo.

KW - bromo-substituted

KW - diketopyrrolopyrrole

KW - hyaluronic acid

KW - photodynamic therapy

KW - photosensitizers

UR - https://www.scopus.com/pages/publications/84969705194

U2 - 10.1021/acsami.6b01533

DO - 10.1021/acsami.6b01533

M3 - 文章

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AN - SCOPUS:84969705194

SN - 1944-8244

VL - 8

SP - 10737

EP - 10742

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 17

ER -

Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy

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