TY - JOUR
T1 - Biological synthesis of metallic nanoparticles (MNPs) by plants and microbes
T2 - their cellular uptake, biocompatibility, and biomedical applications
AU - Ahmad, Fiaz
AU - Ashraf, Noreen
AU - Ashraf, Tayyba
AU - Zhou, Ren Bin
AU - Yin, Da Chuan
N1 - Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Metallic nanoparticles (MNPs) with their diverse physical and chemical properties have been applied in various biomedical domains. The increasing demand for MNPs has attracted researchers to develop straightforward, inexpensive, simple, and eco-friendly processes for the enhanced production of MNPs. To discover new biomedical applications first requires knowledge of the interactions of MNPs with target cells. This review focuses on plant and microbial synthesis of biological MNPs, their cellular uptake, biocompatibility, any biological consequences such as cytotoxicity, and biomedical applications. We highlighted the involvement of biomolecules in capping and stabilization of MNPs and the effect of physicochemical parameters particularly the pH on the synthesis of MNPs. Recently achieved milestones to understand the role of synthetic biology (SynBiol) in the synthesis of tailored MNPs are also discussed.
AB - Metallic nanoparticles (MNPs) with their diverse physical and chemical properties have been applied in various biomedical domains. The increasing demand for MNPs has attracted researchers to develop straightforward, inexpensive, simple, and eco-friendly processes for the enhanced production of MNPs. To discover new biomedical applications first requires knowledge of the interactions of MNPs with target cells. This review focuses on plant and microbial synthesis of biological MNPs, their cellular uptake, biocompatibility, any biological consequences such as cytotoxicity, and biomedical applications. We highlighted the involvement of biomolecules in capping and stabilization of MNPs and the effect of physicochemical parameters particularly the pH on the synthesis of MNPs. Recently achieved milestones to understand the role of synthetic biology (SynBiol) in the synthesis of tailored MNPs are also discussed.
KW - Biocompatibility
KW - Biomedical applications
KW - Cellular uptake
KW - Cytotoxicity
KW - Metallic nanoparticles
KW - Plant and microbial synthesis
UR - https://www.scopus.com/pages/publications/85061693155
U2 - 10.1007/s00253-019-09675-5
DO - 10.1007/s00253-019-09675-5
M3 - 文献综述
C2 - 30778643
AN - SCOPUS:85061693155
SN - 0175-7598
VL - 103
SP - 2913
EP - 2935
JO - Applied Microbiology and Biotechnology
JF - Applied Microbiology and Biotechnology
IS - 7
ER -