TY - JOUR
T1 - Assessing the immediate impact of botulinum toxin injection on impedance of spastic muscle
AU - Li, Xiaoyan
AU - Shin, Henry
AU - Li, Le
AU - Magat, Elaine
AU - Li, Sheng
AU - Zhou, Ping
N1 - Publisher Copyright:
© 2017 IPEM
PY - 2017/5/1
Y1 - 2017/5/1
N2 - This study aimed to investigate the immediate impacts of Botulinum Toxin A (BoNT-A) injections on the inherent electrical properties of spastic muscles using a newly developed electrical impedance myography (EIM) technique. Impedance measures were performed before and after a BoNT-A injection in biceps brachii muscles of 14 subjects with spasticity. Three major impedance variables, resistance (R), reactance (X) and phase angle (θ) were obtained from three different configurations, and were evaluated using the conventional EIM frequency at 50 kHz as well as multiple frequency analysis. Statistical analysis demonstrated a significant decrease of resistance in the injected muscles (Multiple-frequency: Rpre = 25.17 ± 1.94 Ohm, Rpost = 23.65 ± 1.63 Ohm, p < 0.05; 50 kHz: Rpre = 29.06 ± 2.16 Ohm, Rpost = 27.7 ± 1.89 Ohm, p < 0.05). Despite this decrease, there were no substantial changes in the reactance, phase angle, or anisotropy features after a BoNT-A injection. The significant changes of muscle resistance were most likely associated with the liquid injection of the BoNT-A-saline solution rather than the immediate toxin effects on the muscle. This study demonstrated high sensitivity of the EIM technique in the detection of alterations to muscle composition.
AB - This study aimed to investigate the immediate impacts of Botulinum Toxin A (BoNT-A) injections on the inherent electrical properties of spastic muscles using a newly developed electrical impedance myography (EIM) technique. Impedance measures were performed before and after a BoNT-A injection in biceps brachii muscles of 14 subjects with spasticity. Three major impedance variables, resistance (R), reactance (X) and phase angle (θ) were obtained from three different configurations, and were evaluated using the conventional EIM frequency at 50 kHz as well as multiple frequency analysis. Statistical analysis demonstrated a significant decrease of resistance in the injected muscles (Multiple-frequency: Rpre = 25.17 ± 1.94 Ohm, Rpost = 23.65 ± 1.63 Ohm, p < 0.05; 50 kHz: Rpre = 29.06 ± 2.16 Ohm, Rpost = 27.7 ± 1.89 Ohm, p < 0.05). Despite this decrease, there were no substantial changes in the reactance, phase angle, or anisotropy features after a BoNT-A injection. The significant changes of muscle resistance were most likely associated with the liquid injection of the BoNT-A-saline solution rather than the immediate toxin effects on the muscle. This study demonstrated high sensitivity of the EIM technique in the detection of alterations to muscle composition.
KW - Botulinum Toxin A (BoNT-A)
KW - Electrical impedance myography (EIM)
KW - Spasticity
UR - https://www.scopus.com/pages/publications/85011411862
U2 - 10.1016/j.medengphy.2017.01.018
DO - 10.1016/j.medengphy.2017.01.018
M3 - 文章
C2 - 28169197
AN - SCOPUS:85011411862
SN - 1350-4533
VL - 43
SP - 97
EP - 102
JO - Medical Engineering and Physics
JF - Medical Engineering and Physics
ER -